2762275-20-5
2762275-20-5 structure
- Name: PRC2 EED-IN-1
- Chemical Name: PRC2 EED-IN-1
- CAS Number: 2762275-20-5
- Molecular Formula: C19H19FN8O
- Molecular Weight: 394.414
- Create Date: 2022-07-01 20:39:49
- Modify Date: 2024-02-25 11:05:51
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PRC2 EED-IN-1 is a potent, selective, allosteric, orally bioavailable inhibitor of the EED subunit of histone methyltransferase PRC2 with IC50 of 44 nM (H3K27me3 inhibition).PRC2 EED-IN-1 retains efficacy against EZH2 inhibitor-resistant cell lines (Karpas 44 cell IC50=27 nM), exhibits in vivo efficacy in EZH2-driven tumors in vivo.
| Name | PRC2 EED-IN-1 |
|---|
| Description | PRC2 EED-IN-1 is a potent, selective, allosteric, orally bioavailable inhibitor of the EED subunit of histone methyltransferase PRC2 with IC50 of 44 nM (H3K27me3 inhibition).PRC2 EED-IN-1 retains efficacy against EZH2 inhibitor-resistant cell lines (Karpas 44 cell IC50=27 nM), exhibits in vivo efficacy in EZH2-driven tumors in vivo. |
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| References | 1. Bagal SK, et al. J Med Chem. 2021 Dec 9;64(23):17146-17183. |
| Molecular Formula | C19H19FN8O |
|---|---|
| Molecular Weight | 394.414 |