CB1/2 agonist 2
Modify Date: 2024-09-17 21:56:12
CB1/2 agonist 2 structure
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Common Name | CB1/2 agonist 2 | ||
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| CAS Number | 2772379-97-0 | Molecular Weight | 417.62 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H43NO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CB1/2 agonist 2CB1/2 agonist 2 (compound 23) is a potent non-selective cannabinoid ligand, with Ki values of 3.5 and 1.2 nM, respectively. CB1/2 agonist 2 can behave as a full CB1 agonist and CB2 competitive inverse agonist. CB1/2 agonist 2 shows antinociceptive activity[1]. |
| Name | CB1/2 agonist 2 |
|---|
| Description | CB1/2 agonist 2 (compound 23) is a potent non-selective cannabinoid ligand, with Ki values of 3.5 and 1.2 nM, respectively. CB1/2 agonist 2 can behave as a full CB1 agonist and CB2 competitive inverse agonist. CB1/2 agonist 2 shows antinociceptive activity[1]. |
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| Related Catalog | |
| Target |
hCB2-R:1.2 nM (Ki) hCB1-R:3.5 nM (Ki) |
| In Vitro | CB1/2 agonist 2 (compound 23) (1 µM, 24-72 h) exhibits a very low cytotoxic potential in Hep-G2 cells[1]. CB1/2 agonist 2 (0-10 µM) shows a slight but significant inhibition of [35S]GTPγS binding to hCB2-CHO cell membranes, with a mean EC50 of 397.90 nM and a mean Emax value of -17.81%[1]. Cell Cytotoxicity Assay[1] Cell Line: Human hepatoblastoma (Hep-G2) cells Concentration: 1 µM Incubation Time: 24, 48 or 72 h Result: Exhibited a very low cytotoxic potential, as Hep-G2 cell viability was comparable to controls after 24-72 h of treatment. |
| In Vivo | CB1/2 agonist 2 (compound 23) (0-6 mg/kg, IP, once) significantly reduces the late phase of formalin-induced nocifensive behaviour at 6 mg/kg[1]. Animal Model: Male CD-1 outbred mice (40-45 g)[1] Dosage: 0, 1, 3, and 6 mg/kg Administration: IP, once, 10 min before the formalin or saline injection Result: Significantly reduced the late phase of formalin-induced nocifensive behaviour at the highest dose (6 mg/kg, i.p.), whereas no effect was produced by doses of 1 and 3 mg/kg. |
| References |
| Molecular Formula | C26H43NO3 |
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| Molecular Weight | 417.62 |