Etidronic acid

Modify Date: 2024-01-02 10:08:27

Etidronic acid Structure
Etidronic acid structure
 Common Name Etidronic acid
CAS Number 2809-21-4 Molecular Weight 206.028
Density 2.1±0.1 g/cm3 Boiling Point 578.8±60.0 °C at 760 mmHg
Molecular Formula C2H8O7P2 Melting Point 198~199℃
MSDS Chinese USA Flash Point 303.8±32.9 °C
Symbol GHS05
GHS05		 Signal Word Danger

 Use of Etidronic acid


Etidronic acid is a bisphosphonate used in detergents, water treatment, cosmetics and pharmaceutical treatment.Target: OthersEtidronic Acid is a chelating agent and may be added to bind to or counter the effects of substances such as arsenic, iron, or other metal ions that can occur in the presence of some soaps. Etidronic acid also acts to retard oxidation of fatty acids. For clarification, a chelator, or chelating agent is a binding component added to many cosmetics, beauty products, and water softeners to form multiple bonds with a single metal ion and neutralize it.

 Names

Name etidronic acid
Synonym More Synonyms

 Etidronic acid Biological Activity

Description Etidronic acid is a bisphosphonate used in detergents, water treatment, cosmetics and pharmaceutical treatment.Target: OthersEtidronic Acid is a chelating agent and may be added to bind to or counter the effects of substances such as arsenic, iron, or other metal ions that can occur in the presence of some soaps. Etidronic acid also acts to retard oxidation of fatty acids. For clarification, a chelator, or chelating agent is a binding component added to many cosmetics, beauty products, and water softeners to form multiple bonds with a single metal ion and neutralize it.
Related Catalog
References

[1]. http://www.truthinaging.com/ingredients/etidronic-acid

 Chemical & Physical Properties

Density 2.1±0.1 g/cm3
Boiling Point 578.8±60.0 °C at 760 mmHg
Melting Point 198~199℃
Molecular Formula C2H8O7P2
Molecular Weight 206.028
Flash Point 303.8±32.9 °C
Exact Mass 205.974518
PSA 154.91000
LogP -3.54
Vapour Pressure 0.0±3.6 mmHg at 25°C
Index of Refraction 1.586
Stability Stable. Incompatible with strong oxidizing agents.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SZ8562100
CHEMICAL NAME :
Phosphonic acid, (1-hydroxyethylidene)di-
CAS REGISTRY NUMBER :
2809-21-4
BEILSTEIN REFERENCE NO. :
1789291
LAST UPDATED :
199710
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C2-H8-O7-P2
MOLECULAR WEIGHT :
206.04

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ACIEAY Angewandte Chemie, International Edition in English. (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.1- 1962- Volume(issue)/page/year: 14,94,1975 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
40 mg/kg
SEX/DURATION :
female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
SIGAAE Shika Igaku. Odontology. (Osaka Shika Gakkai, 1-47 Kyobashi, Higashi-ku, Osaka 540, Japan) V.1- 1930- Volume(issue)/page/year: 50,879,1987
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
200 mg/kg
SEX/DURATION :
female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow)
REFERENCE :
JODUA2 Journal of Osaka Dental University. (Osaka Dental Univ., 1-47, Kyobashi Higashi-ku, Osaka 540, Japan) V.1- 1967- Volume(issue)/page/year: 20,91,1986
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
200 mg/kg
SEX/DURATION :
female 7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
JODUA2 Journal of Osaka Dental University. (Osaka Dental Univ., 1-47, Kyobashi Higashi-ku, Osaka 540, Japan) V.1- 1967- Volume(issue)/page/year: 19,87,1985
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
200 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
REFERENCE :
SIGAAE Shika Igaku. Odontology. (Osaka Shika Gakkai, 1-47 Kyobashi, Higashi-ku, Osaka 540, Japan) V.1- 1930- Volume(issue)/page/year: 49,837,1986
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
200 mg/kg
SEX/DURATION :
female 13 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968- Volume(issue)/page/year: 26(1),16A,1982
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
1400 mg/kg
SEX/DURATION :
female 11-17 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 22,47,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0985 No. of Facilities: 404 (estimated) No. of Industries: 10 No. of Occupations: 7 No. of Employees: 6655 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0985 No. of Facilities: 3273 (estimated) No. of Industries: 73 No. of Occupations: 46 No. of Employees: 44885 (estimated) No. of Female Employees: 3814 (estimated)

 Safety Information

Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H290-H318
Precautionary Statements P280-P305 + P351 + P338
Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xi
Risk Phrases 37/38-41
Safety Phrases S26-S39
RIDADR UN 3265
WGK Germany 2
RTECS SZ8562100
Packaging Group II
Hazard Class 8
HS Code 2931900090

 Synthetic Route

 Customs

HS Code 2931900090
Summary 2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0%

 Articles36

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 Synonyms

(1-Hydroxyethane-1,1-diyl)diphosphonic acid
Etidronsaeure
Acetodiphosphonic acid
ethane-1-hydroxy-1,1-diphosphonic acid
MFCD00070585
1-hydroxyethane 1,1-diphosphonic acid
Hydroxyethanediphosphonic acid
EHDP
Phosphonic acid, (1-hydroxyethylidene)bis-
Osteoscan
(1-hydroxyethane-1,1-diyl)bis(phosphonic acid)
1-Hydroxyethylidenediphosphonic acid
1-Hydroxyethylidene-1,1-diphosphonic Acid
(1-hydroxy-1-phosphonoethyl)phosphonic acid
Didronel IV
ethane-1-hydroxy-1,1-bisphosphonic acid
acide etidronique
EINECS 220-552-8
Oxyethylidenediphosphonic acid
HEDP
1-Hydroxyeth
Etidronic acid monohydrate (HEDP)
DEQUEST 2010
Turpinal SL
Etidronic acid
(1-Hydroxy-1,1-ethanediyl)bis(phosphonic acid)
acidum etidronicum
Etidronate
1-Hydroxyethane-1,1-diphosphonic acid
acido etidronico
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