Cyclo(-leu-pro)

Modify Date: 2024-01-02 04:40:44

Cyclo(-leu-pro) Structure
Cyclo(-leu-pro) structure
Common Name Cyclo(-leu-pro)
CAS Number 2873-36-1 Molecular Weight 210.27
Density 1.1±0.1 g/cm3 Boiling Point 427.6±34.0 °C at 760 mmHg
Molecular Formula C11H18N2O2 Melting Point 163-165ºC
MSDS N/A Flash Point 212.4±25.7 °C

 Use of Cyclo(-leu-pro)


Cyclo(L-Leu-L-Pro) is an inhibitory substance targeting to production of norsolorinic acid (NA,a precursor of aflatoxin),which can be isolated from A. xylosoxidans NFRI-A1. Cyclo(L-Leu-L-Pro) inhibits accumulation of NA by A. parasiticus NFRI-95 and inhibits spore formation. Cyclo(L-Leu-L-Pro) inhibits aflatoxin production with an IC50 of 0.2 mg/mL in A. parasiticus SYS-4[1].

 Names

Name 3-(2-methylpropyl)-2,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Synonym More Synonyms

 Cyclo(-leu-pro) Biological Activity

Description Cyclo(L-Leu-L-Pro) is an inhibitory substance targeting to production of norsolorinic acid (NA,a precursor of aflatoxin),which can be isolated from A. xylosoxidans NFRI-A1. Cyclo(L-Leu-L-Pro) inhibits accumulation of NA by A. parasiticus NFRI-95 and inhibits spore formation. Cyclo(L-Leu-L-Pro) inhibits aflatoxin production with an IC50 of 0.2 mg/mL in A. parasiticus SYS-4[1].
Related Catalog
References

[1]. Yan PS, et al. Cyclo(L-leucyl-L-prolyl) produced by Achromobacter xylosoxidans inhibits aflatoxin production by Aspergillus parasiticus. Appl Environ Microbiol. 2004 Dec;70(12):7466-73.  

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 427.6±34.0 °C at 760 mmHg
Melting Point 163-165ºC
Molecular Formula C11H18N2O2
Molecular Weight 210.27
Flash Point 212.4±25.7 °C
Exact Mass 210.136826
PSA 49.41000
LogP -0.84
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.530

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UY8708800
CHEMICAL NAME :
Pyrrolo(1,2-a)pyrazine-1,4-dione, hexahydro-3-isobutyl-, stereoisomer
CAS REGISTRY NUMBER :
2873-36-1
BEILSTEIN REFERENCE NO. :
0085716
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C11-H18-N2-O2
MOLECULAR WEIGHT :
210.31

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Tumorigenic - facilitates action of known carcinogen
REFERENCE :
85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 2,1354,1978

 Safety Information

HS Code 2933990090

 Synthetic Route

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Gancidin W
CYCLO(L-LEU-L-PRO)
(3S-trans)-Hexahydro-3-isobutylpyrrolo(1,2-a)pyrazine-1,4-dione
Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-3-(2-methylpropyl)-, (3S,8aS)-
cyclo-L-Leu-L-Pro
EINECS 220-710-6
(3S,8aS)-3-Isobutylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione
Cyclo(-Leu-Pro)
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