Ursodeoxycholic acid sodium

Modify Date: 2024-01-07 09:29:04

Ursodeoxycholic acid sodium structure	Common Name	Ursodeoxycholic acid sodium
	CAS Number	2898-95-5	Molecular Weight	414.554
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₃₉NaO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Ursodeoxycholic acid sodium

Ursodeoxycholic acid (Ursodeoxycholate) sodium is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid sodium acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid sodium can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active[1][2].

Name	NaUDCh
Synonym	More Synonyms

Description	Ursodeoxycholic acid (Ursodeoxycholate) sodium is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid sodium acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid sodium can be used for the research of a variety of hepatic and gastrointestinal diseases. Orally active[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> FXR Signaling Pathways >> GPCR/G Protein >> GPCR19 Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
Target	Microbial Metabolite
In Vivo	Ursodeoxycholic acid (50, 150, and 450 mg/kg; p.o.; daily for 21 days) sodium results in weight loss in C57BL/6J wildtype mice[1]. Animal Model: 5 week old C57BL/6J WT mice (male and female)[1] Dosage: 50, 150, and 450 mg/kg dissolved in corn oil Administration: Oral gavage; daily for 21 days Result: Mice in the 50 and 450 mg/kg groups sustained significant weight loss within a week. At 50 mg/kg, this weight loss persisted over the course of the experiment. At 450 mg/kg, initially weight loss was noted during the first and third week of ursodiol administration. At 150 mg/kg, it did not have significantly different weights compared to the untreated mice.
References	[1]. Winston JA, et al. Secondary bile acid ursodeoxycholic acid alters weight, the gut microbiota, and the bile acid pool in conventional mice. PLoS One. 2021;16(2):e0246161. Published 2021 Feb 18. [2]. Goossens JF, et al. Ursodeoxycholic acid and cancer: From chemoprevention to chemotherapy. Pharmacol Ther. 2019;203:107396.