ER degrader 7

Modify Date: 2024-02-02 16:23:53

ER degrader 7 structure	Common Name	ER degrader 7
	CAS Number	2922929-63-1	Molecular Weight	736.63
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₃H₃₁F₄N₃O₅SSe	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ER degrader 7

ER degrader 7 (Compound 35t) is an ERα and ERβ degrader. ER degrader 7 inhibits tubulin polymerization. ER degrader 7 inhibits cell viability with IC50s of 0.06, 2.56, 15.84, 1.59, 1.67, 1.37 μM for MCF-7, T47D, MCF-10A, LCC2, T47D D538G, and T47D Y537S cells respectively. ER degrader 7 also inhibits breast cancer tumor growth[1].

Name	ER degrader 7

Description	ER degrader 7 (Compound 35t) is an ERα and ERβ degrader. ER degrader 7 inhibits tubulin polymerization. ER degrader 7 inhibits cell viability with IC50s of 0.06, 2.56, 15.84, 1.59, 1.67, 1.37 μM for MCF-7, T47D, MCF-10A, LCC2, T47D D538G, and T47D Y537S cells respectively. ER degrader 7 also inhibits breast cancer tumor growth[1].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
References	[1]. Deng X, et al. Identification of Novel Dual-Target Estrogen Receptor α Degraders with Tubulin Inhibitory Activity for the Treatment of Endocrine-Resistant Breast Cancer. J Med Chem. 2023 Aug 24;66(16):11094-11117.

Molecular Formula	C₃₃H₃₁F₄N₃O₅SSe
Molecular Weight	736.63

ER degrader 7

Use of ER degrader 7

Names

ER degrader 7 Biological Activity

Chemical & Physical Properties