Cyclen

Modify Date: 2024-01-02 05:52:40

Cyclen Structure
Cyclen structure
 Common Name Cyclen
CAS Number 294-90-6 Molecular Weight 172.27
Density 0.9±0.1 g/cm3 Boiling Point 283.8±8.0 °C at 760 mmHg
Molecular Formula C8H20N4 Melting Point 110-113 °C(lit.)
MSDS Chinese USA Flash Point 129.5±13.5 °C
Symbol GHS05 GHS07 GHS09
GHS05, GHS07, GHS09		 Signal Word Danger

 Use of Cyclen


Cyclen is the aza analogue of crown ether, used as a precursor for MRI contrast agents, and is an intermediate for the preparation of effective macrocyclic chelates[1].

 Names

Name 1,4,7,10-tetraazacyclododecane
Synonym More Synonyms

 Cyclen Biological Activity

Description Cyclen is the aza analogue of crown ether, used as a precursor for MRI contrast agents, and is an intermediate for the preparation of effective macrocyclic chelates[1].
Related Catalog
References

[1]. Rashid HU, et al. Cyclen-based Gd3+ complexes as MRI contrast agents: Relaxivity enhancement and ligand design. Bioorg Med Chem. 2016 Nov 15;24(22):5663-5684.

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 283.8±8.0 °C at 760 mmHg
Melting Point 110-113 °C(lit.)
Molecular Formula C8H20N4
Molecular Weight 172.27
Flash Point 129.5±13.5 °C
Exact Mass 172.168793
PSA 48.12000
LogP -2.34
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.424
Storage condition Refrigerator

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XA5253000
CHEMICAL NAME :
1,4,7,10-Tetraazacyclododecane
CAS REGISTRY NUMBER :
294-90-6
BEILSTEIN REFERENCE NO. :
0606114
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C8-H20-N4
MOLECULAR WEIGHT :
172.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
388 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1913- Volume(issue)/page/year: 70,201,1983
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
435 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 19,425,1984

 Safety Information

Symbol GHS05 GHS07 GHS09
GHS05, GHS07, GHS09
Signal Word Danger
Hazard Statements H302-H312-H314-H410
Precautionary Statements P273-P280-P305 + P351 + P338-P310-P501
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant;
Risk Phrases R36/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS XA5253000
Packaging Group I; II; III
HS Code 2933990090

 Synthetic Route

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles31

More Articles
Discovery of new small molecules that influence neuroblast cell migration from the subventricular zone.

Bioorg. Med. Chem. Lett. 18 , 169-74, (2008)

Using SVZ (subventricular zone) tissue explants from one-day-old mice, we investigated the activity of new amino aromatic disulfide analogues and polyazamacrocycles on the migration of SVZ cells (neur...

Monopicolinate cyclen and cyclam derivatives for stable copper(II) complexation.

Inorg. Chem. 51(12) , 6916-27, (2012)

The syntheses of a new 1,4,7,10-tetraazacyclododecane (cyclen) derivative bearing a picolinate pendant arm (HL1), and its 1,4,8,11-tetraazacyclotetradecane (cyclam) analogue HL2, were achieved by usin...

Copper and cobalt complexes of octadentate azamacrocycles: spectrophotometric titration, stopped-flow kinetics and crystallographic study.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 83(1) , 525-31, (2011)

Details of complex formation kinetics are reported for tetrakis(2-hydroxyethyl) substituted cyclen (L(1)) and cyclam (L(2)) with Cu(II) and Co(II). Stopped-flow kinetics and spectroscopic titration me...

 Synonyms

Tetraaza-12-crown-4
T-12-M DM GM JMTJ
Cyclen
1,4,7,10-tetrazacyclododecane
MFCD00066281
1,4,7,10-Tetraazacyclododecane
5-26-11-00023 (Beilstein Handbook Reference)
[12]aneN4
1,4,7,12-tetraazacyclodedecane
EINECS 202-928-3
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Cyclen suppliers

Price: ￥770/10 mM * 1 mL in DMSO

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Chemsrc provides Cyclen(CAS#:294-90-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Cyclen are included as well.>> amp version: Cyclen

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