2,4(1H,3H)-Pyrimidinedione,1-b-D-arabinofuranosyldihydro-

Modify Date: 2024-02-08 15:56:56

2,4(1H,3H)-Pyrimidinedione,1-b-D-arabinofuranosyldihydro- Structure
2,4(1H,3H)-Pyrimidinedione,1-b-D-arabinofuranosyldihydro- structure
Common Name 2,4(1H,3H)-Pyrimidinedione,1-b-D-arabinofuranosyldihydro-
CAS Number 30100-83-5 Molecular Weight 246.22
Density 1.614g/cm3 Boiling Point N/A
Molecular Formula C9H14N2O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 2,4(1H,3H)-Pyrimidinedione,1-b-D-arabinofuranosyldihydro-


5,6-Dihydro-ara-uridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-diazinane-2,4-dione
Synonym More Synonyms

  Biological Activity

Description 5,6-Dihydro-ara-uridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 1.614g/cm3
Molecular Formula C9H14N2O6
Molecular Weight 246.22
Exact Mass 246.08500
PSA 122.82000
Index of Refraction 1.613

 Synthetic Route

~90%

2,4(1H,3H)-Pyrimidinedione,1-b-D-arabinofuranosyldihydro- Structure

2,4(1H,3H)-Pyri...

CAS#:30100-83-5

Literature: Skaric, Vinko; Matulic-Adamic, Jasenka Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 779 - 784

 Precursor & DownStream

Precursor  1

DownStream  0

 Synonyms

5,5-dideuterio-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-diazinane-2,4-dione
Uridine,5,6-dihydro
Dihydrouridin