Depramine

Modify Date: 2024-01-12 13:00:28

Depramine Structure
Depramine structure
Common Name Depramine
CAS Number 303-54-8 Molecular Weight 278.39
Density 1.06g/cm3 Boiling Point 413.9ºC at 760mmHg
Molecular Formula C19H22N2 Melting Point N/A
MSDS N/A Flash Point 185.9ºC

 Use of Depramine


Depramine (GP 31406) is a tricyclic antidepressant with pharmacologically activity. Depramine inhibits acetylcholinesterase,Mg2+-ATPase,and Na+/K+ ATPase activity[1][2].

 Names

Name 3-benzo[b][1]benzazepin-11-yl-N,N-dimethylpropan-1-amine
Synonym More Synonyms

 Depramine Biological Activity

Description Depramine (GP 31406) is a tricyclic antidepressant with pharmacologically activity. Depramine inhibits acetylcholinesterase,Mg2+-ATPase,and Na+/K+ ATPase activity[1][2].
Related Catalog
Target

Acetylcholinesterase (AChE), Mg2+-ATPase, Na+/K+ ATPase[1]

References

[1]. Caratsch CG, et al. Tricyclic antidepressants: action on synaptosomal acetylcholinesterase and ATPase in the brain of guinea pigs and subcellular distribution. Neuropharmacology. 1973 Jun;12(6):563-75.  

 Chemical & Physical Properties

Density 1.06g/cm3
Boiling Point 413.9ºC at 760mmHg
Molecular Formula C19H22N2
Molecular Weight 278.39
Flash Point 185.9ºC
Exact Mass 278.17800
PSA 6.48000
LogP 4.32520
Index of Refraction 1.589

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HO1480000
CHEMICAL NAME :
5H-Dibenz(b,f)azepine, 5-(3-(dimethylamino)propyl)-
CAS REGISTRY NUMBER :
303-54-8
BEILSTEIN REFERENCE NO. :
1319717
LAST UPDATED :
199712
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C19-H22-N2
MOLECULAR WEIGHT :
278.43
WISWESSER LINE NOTATION :
T C676 BNJ B3N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
23 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 120,450,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
41 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 120,450,1959
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
6 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 120,450,1959

 Safety Information

HS Code 2933990090

 Synthetic Route

~%

Depramine Structure

Depramine

CAS#:303-54-8

Literature: Schmolka; Zimmer Synthesis, 1984 , vol. NO. 1, p. 29 - 31

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

(3-dibenzo[b,f]azepin-5-yl-propyl)-dimethyl-amine
Depramine
Depramina [INN-Spanish]
5-(3-(Dimethylamino)propyl)-5H-dibenz(b,f)azepine
10,11-Dehydroimipramine
5H-Dibenz(b,f)azepine,5-(3-(dimethylamino)propyl)
Depraminum [INN-Latin]
5-(8-Dimethylaminopropyl)-iminostilben
Balipramine
5-(3'-Dimethyl-amino-propyl)-5H-dibenz<b,f>azepin