Kynuramine Dihydrobromide

Modify Date: 2024-01-05 11:09:35

Kynuramine Dihydrobromide Structure
Kynuramine Dihydrobromide structure
Common Name Kynuramine Dihydrobromide
CAS Number 304-47-2 Molecular Weight 326.02800
Density N/A Boiling Point 367.3ºC at 760mmHg
Molecular Formula C9H14Br2N2O Melting Point N/A
MSDS Chinese USA Flash Point 175.9ºC

 Use of Kynuramine Dihydrobromide


Kynuramine (dihydrobromide), an endogenously occurring amine, is a fluorescent substrate and probe of plasma amine oxidase[1][2].

 Names

Name Kynuramine dihydrobromide
Synonym More Synonyms

 Kynuramine Dihydrobromide Biological Activity

Description Kynuramine (dihydrobromide), an endogenously occurring amine, is a fluorescent substrate and probe of plasma amine oxidase[1][2].
Related Catalog
In Vitro Kynuramine (dihydrobromide) 在体外抑制突触前和突触后 α-肾上腺素受体[2]。 Kynuramine 已被证明是狗脑动脉血清素受体的部分激动剂[2]。 Kynuramine (20 μg/mL) 经常导致回肠轻微收缩,但未能改变胆碱能刺激的抽搐反应[2]。
In Vivo Kynuramine (dihydrobromide) (0.064、0.32、1.6 或 8 μg;脑室内;单剂量) 促进雌激素激发的去卵巢大鼠前凸行为[3]。 Kynuramine (1.25、2.5 和 5.0 mg/kg;静脉注射;单剂量) 可增加大鼠的心率和血压[4]。 Animal Model: Female rats[3]. Dosage: 0.064-8 μg. Administration: Intraventricular injection; single does. Result: Produced facilitation of lordosis behavior. Animal Model: Male rats (about 200g)[4]. Dosage: 1.25-5.0 mg/kg. Administration: Intravenous injection; single does. Result: Promoted heart rate and blood pressure.
References

[1]. J B Massey, et al. Kynuramine, a fluorescent substrate and probe of plasma amine oxidase. J Biol Chem. 1977 Nov 25;252(22):8081-4.  

[2]. T D Johnson, An alpha-adrenoceptor inhibitory action of kynuramine. Eur J Pharmacol. 1981 Jul 10;72(4):351-6.  

[3]. S D Mendelson, et al. Intraventricular administration of l-kynurenine and kynuramine facilitates lordosis in the female rat. Eur J Pharmacol. 1987 Oct 27;142(3):447-51.  

[4]. T D Johnson, et al. Blood pressure and heart rate effects of kynuramine in pithed rats. Eur J Pharmacol. 1983 Feb 18;87(2-3):323-6.  

 Chemical & Physical Properties

Boiling Point 367.3ºC at 760mmHg
Molecular Formula C9H14Br2N2O
Molecular Weight 326.02800
Flash Point 175.9ºC
Exact Mass 323.94700
PSA 69.11000
LogP 3.99800
Storage condition 20°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3

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 Synonyms

3-(2-Aminophenyl)-3-oxopropanamine
3-amino-1-(2-aminophenyl)propan-1-one,hydrobromide