4-(2,4-Dichlorophenyl)-1,4-dihydro-[1,3,5]triazino[1,2-a]benzimidazol-2-amine

Modify Date: 2024-07-17 18:09:12

4-(2,4-Dichlorophenyl)-1,4-dihydro-[1,3,5]triazino[1,2-a]benzimidazol-2-amine structure	Common Name	4-(2,4-Dichlorophenyl)-1,4-dihydro-[1,3,5]triazino[1,2-a]benzimidazol-2-amine
	CAS Number	305343-00-4	Molecular Weight	332.19
	Density	1.7±0.1 g/cm3	Boiling Point	493.6±55.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₁Cl₂N₅	Melting Point	N/A
	MSDS	N/A	Flash Point	252.3±31.5 °C

Use of 4-(2,4-Dichlorophenyl)-1,4-dihydro-[1,3,5]triazino[1,2-a]benzimidazol-2-amine

Topoisomerase II inhibitor 14 (compound 2f) is a potent inhibtor of Topoisomerase II, with anticancer activity. Topoisomerase II inhibitor 14 induces apoptosis, and arrests cell cycle at S phase. Topoisomerase II inhibitor 14 exhibits antioxidant effect and decreases the level of GSH, MDA, and NO[1].

Name	4-(2,4-Dichlorophenyl)-4,10-dihydro[1,3,5]triazino[1,2-a]benzimidazol-2-amine
Synonym	More Synonyms

Description	Topoisomerase II inhibitor 14 (compound 2f) is a potent inhibtor of Topoisomerase II, with anticancer activity. Topoisomerase II inhibitor 14 induces apoptosis, and arrests cell cycle at S phase. Topoisomerase II inhibitor 14 exhibits antioxidant effect and decreases the level of GSH, MDA, and NO[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
In Vivo	Topoisomerase II inhibitor 14 (compound 2f)
References	[1]. Al-Karmalawy AA, et al. Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and biological assessments. Eur J Med Chem. 2023 Nov 5;259:115661.

Density	1.7±0.1 g/cm3
Boiling Point	493.6±55.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₁Cl₂N₅
Molecular Weight	332.19
Flash Point	252.3±31.5 °C
Exact Mass	331.039154
LogP	3.08
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.801

1,3,5-triazino[1,2-a]benzimidazol-2-amine, 4-(2,4-dichlorophenyl)-3,4-dihydro-

1,3,5-Triazino[1,2-a]benzimidazol-2-amine, 4-(2,4-dichlorophenyl)-4,10-dihydro-

4-(2,4-Dichlorophenyl)-4,10-dihydro[1,3,5]triazino[1,2-a]benzimidazol-2-amine

MFCD06592467

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4-(2,4-Dichlorophenyl)-1,4-dihydro-[1,3,5]triazino[1,2-a]benzimidazol-2-amine

Use of 4-(2,4-Dichlorophenyl)-1,4-dihydro-[1,3,5]triazino[1,2-a]benzimidazol-2-amine

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