LMP744 hydrochloride
Modify Date: 2024-01-02 17:43:32
LMP744 hydrochloride structure
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Common Name | LMP744 hydrochloride | ||
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| CAS Number | 308246-57-3 | Molecular Weight | 488.91800 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H25ClN2O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of LMP744 hydrochlorideLMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase (Top1) inhibitor with antitumor activity[1]. |
| Name | 6-[3-[(2-Hydroxyethyl)amino]propyl]-5,11-diketo-2,3-dimethoxy-8,9-(methylenedioxy)-11H-indeno[1,2-c]isoquinoline Hydrochloride |
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| Synonym | More Synonyms |
| Description | LMP744 hydrochloride (MJ-III65 hydrochloride) is a DNA intercalator and Topoisomerase (Top1) inhibitor with antitumor activity[1]. |
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| Related Catalog | |
| Target |
Top1[1]. |
| In Vitro | The GI50 value of LMP744 (MJ-III-65) for NCI60 cells is 0.1 μM[1]. LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle[1]. Cell Cytotoxicity Assay[1] Cell Line: P388 and P388 Top1-deficient murine leukemia cells Concentration: 0.1-100 μM Incubation Time: 3 days Result: induced dose-dependent accumulation of cells in the S and G2 phases of the cell cycle |
| In Vivo | MJ-III-65 (10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against human A253 and FaDu tumor xenografts without significant toxicity[2]. Animal Model: Athymic nude mice (nu/nu, female, 20-25 g, 8-12 weeks old) transplanted with A253 and FaDu human head and neck xenografts[2]. Dosage: 10, 25, or 50 mg/kg/week, 4 weeks Administration: i.v. push via tail vein Result: moderately actived against human A253 and FaDu tumor xenografts without significant toxicity |
| References |
| Molecular Formula | C24H25ClN2O7 |
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| Molecular Weight | 488.91800 |
| Exact Mass | 488.13500 |
| PSA | 108.25000 |
| LogP | 3.12370 |
| Storage condition | 2-8℃ |
| 5H-[1,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione,6-[3-[(2-hydroxyethyl)amino]propyl]-2,3-dimethoxy-,monohydrochloride |