Benzo[b][1,8]naphthyridin-5-amine, 2,4,7,9-tetramethyl- (9CI)

Modify Date: 2024-04-01 18:54:30

Benzo[b][1,8]naphthyridin-5-amine, 2,4,7,9-tetramethyl- (9CI) Structure
Benzo[b][1,8]naphthyridin-5-amine, 2,4,7,9-tetramethyl- (9CI) structure
Common Name Benzo[b][1,8]naphthyridin-5-amine, 2,4,7,9-tetramethyl- (9CI)
CAS Number 309726-06-5 Molecular Weight 251.32600
Density N/A Boiling Point N/A
Molecular Formula C16H17N3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Benzo[b][1,8]naphthyridin-5-amine, 2,4,7,9-tetramethyl- (9CI)


BMH-22, a benzonaphthyridin, is a RNA polymerase I (Pol I) transcription inhibitor independent of p53 function. BMH-22 causes reorganization of nucleolar marker proteins consistent with segregation of the nucleolus. BMH-22 destabilizes RPA194 in a proteasome-dependent manner and inhibits nascent rRNA synthesis and expression of the 45S rRNA precursor. BMH-22 shows potent anticancer activity across many tumor types[1].

 Names

Name 2,4,7,9-tetramethylbenzo[b][1,8]naphthyridin-5-amine

  Biological Activity

Description BMH-22, a benzonaphthyridin, is a RNA polymerase I (Pol I) transcription inhibitor independent of p53 function. BMH-22 causes reorganization of nucleolar marker proteins consistent with segregation of the nucleolus. BMH-22 destabilizes RPA194 in a proteasome-dependent manner and inhibits nascent rRNA synthesis and expression of the 45S rRNA precursor. BMH-22 shows potent anticancer activity across many tumor types[1].
Related Catalog
References

[1]. RPA194, rRNA synthesis, 45S Rrna, anticancerKarita Peltonen, et al. Small molecule BMH-compounds that inhibit RNA polymerase I and cause nucleolar stress. Mol Cancer Ther. 2014 Nov;13(11):2537-46.  

 Chemical & Physical Properties

Molecular Formula C16H17N3
Molecular Weight 251.32600
Exact Mass 251.14200
PSA 51.80000
LogP 4.18000

 Safety Information

HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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