Lofexidine

Modify Date: 2024-01-04 23:08:25

Lofexidine structure	Common Name	Lofexidine
	CAS Number	31036-80-3	Molecular Weight	259.132
	Density	1.4±0.1 g/cm3	Boiling Point	421.5±35.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₂Cl₂N₂O	Melting Point	215-225 °C
	MSDS	N/A	Flash Point	208.7±25.9 °C

Use of Lofexidine

Lofexidine is a selective α2-receptor agonist, commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal[1][2].

Name	lofexidine
Synonym	More Synonyms

Description	Lofexidine is a selective α2-receptor agonist, commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
Target	α2-receptor[1][2].
References	[1]. Vartak AP, et al. The preclinical discovery of lofexidine for the treatment of opiate addiction. Expert Opin Drug Discov. 2014 Nov;9(11):1371-7. [2]. Gish EC, et al. Lofexidine, an {alpha}2-receptor agonist for opioid detoxification. Ann Pharmacother. 2010 Feb;44(2):343-51.

Density	1.4±0.1 g/cm3
Boiling Point	421.5±35.0 °C at 760 mmHg
Melting Point	215-225 °C
Molecular Formula	C₁₁H₁₂Cl₂N₂O
Molecular Weight	259.132
Flash Point	208.7±25.9 °C
Exact Mass	258.032654
PSA	33.62000
LogP	3.59
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.611
Storage condition	-20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ2568000

CHEMICAL NAME :: 2-Imidazoline 2-(1-(2,6-dichlorophenoxy)ethyl)-

CAS REGISTRY NUMBER :: 31036-80-3

LAST UPDATED :: 198912

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C11-H12-Cl2-N2-O

MOLECULAR WEIGHT :: 259.15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 8320 ug/kg

SEX/DURATION :: female 8-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 9,559,1988

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 8320 ug/kg

SEX/DURATION :: female 8-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :: NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 9,551,1988

Safety Phrases	S24/25
WGK Germany	3

MFCD00865915

2-{1-[(2,6-dichlorophenyl)oxy]ethyl}-4,5-dihydro-1H-imidazole

2-(a-(2,6-dichlorophenoxy)ethyl)2-imidazoline

Lofexidinum [INN-Latin]

Lofexidina

1H-Imidazole, 2-[1-(2,6-dichlorophenoxy)ethyl]-4,5-dihydro-

Britlofex

Lofexidine

(±)-2-[1-(2,6-Dichlorophenoxy)ethyl]-2-imidazoline

Lofexidinum

Lofexidine [INN:BAN]

Lofexidina [INN-Spanish]

2-[1-(2,6-dichlorophenoxy)ethyl]-2-imidazoline

UNII:UI82K0T627

(-)-2-[1-(2,6-dichlorophenoxy)-ethyl]-1,3-diazacyclopent-2-ene

2-[1-(2,6-Dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole

rac-2-[1-(2,6-dichlorophenoxy)ethyl]-1,3-diazacyclopent-2-ene

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Lofexidine
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Lofexidine
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Lofexidine suppliers

Price: ￥1320/10 mM * 1 mL in DMSO

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Lofexidine

Use of Lofexidine

Names

Lofexidine Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synonyms