SYM 2081

Modify Date: 2024-01-08 17:11:01

SYM 2081 Structure
SYM 2081 structure
Common Name SYM 2081
CAS Number 31137-74-3 Molecular Weight 161.16
Density N/A Boiling Point 329.4ºC at 760mmHg
Molecular Formula C6H11NO4 Melting Point N/A
MSDS N/A Flash Point 153ºC

 Use of SYM 2081


SYM 2081 is a high-affinity ligand and potent, selective agonist of kainate receptors, inhibits [3H]-kainate binding with an IC50 of 35 nM, almost 3000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively[1].

 Names

Name (2S,4R)-4-Methylglutamic Acid
Synonym More Synonyms

 SYM 2081 Biological Activity

Description SYM 2081 is a high-affinity ligand and potent, selective agonist of kainate receptors, inhibits [3H]-kainate binding with an IC50 of 35 nM, almost 3000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively[1].
Related Catalog
Target

IC50: 35 nM (kainate receptors)[1]

References

[1]. Lee JY, et al. Furthering pharmacological and physiological assessment of the glutamatergic receptors at the Drosophila neuromuscular junction. Comp Biochem Physiol C Toxicol Pharmacol. 2009 Nov;150(4):546-57.

 Chemical & Physical Properties

Boiling Point 329.4ºC at 760mmHg
Molecular Formula C6H11NO4
Molecular Weight 161.16
Flash Point 153ºC
Exact Mass 161.06900
PSA 100.62000
LogP 0.20940
Appearance of Characters solid | white
Storage condition Store at RT
Water Solubility H2O: >10 mg/mL

 Safety Information

WGK Germany 3
HS Code 2922499990

 Synthetic Route

 Customs

HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

 Synonyms

(2S,4R)-4-Methylglutamic acid
(2S,4R)-2-azaniumyl-4-methylpentanedioate
MFCD00937765