2-Ketoglutaric acid

Modify Date: 2024-01-01 17:35:52

2-Ketoglutaric acid Structure
2-Ketoglutaric acid structure
 Common Name 2-Ketoglutaric acid
CAS Number 328-50-7 Molecular Weight 146.098
Density 1.5±0.1 g/cm3 Boiling Point 345.6±25.0 °C at 760 mmHg
Molecular Formula C5H6O5 Melting Point 113-115 °C
MSDS Chinese USA Flash Point 177.0±19.7 °C
Symbol GHS05
GHS05		 Signal Word Danger

 Use of 2-Ketoglutaric acid


2-Ketoglutaric acid is an intermediate compound of the Krebs cycle and is also connected to glutamic acid and glutamine metabolisms through the transamination reactions.

 Names

Name 2-oxoglutaric acid
Synonym More Synonyms

 2-Ketoglutaric acid Biological Activity

Description 2-Ketoglutaric acid is an intermediate compound of the Krebs cycle and is also connected to glutamic acid and glutamine metabolisms through the transamination reactions.
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Rocchiccioli F, et al. Microdetermination of 2-ketoglutaric acid in plasma and cerebrospinal fluid by capillary gas chromatography mass spectrometry; application to pediatrics. Biomed Mass Spectrom. 1984 Jan;11(1):24-8.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 345.6±25.0 °C at 760 mmHg
Melting Point 113-115 °C
Molecular Formula C5H6O5
Molecular Weight 146.098
Flash Point 177.0±19.7 °C
Exact Mass 146.021530
PSA 91.67000
LogP -1.43
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 1.494
Storage condition 2-8°C

 Safety Information

Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H318
Precautionary Statements P280-P305 + P351 + P338 + P310
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi,T
Risk Phrases R37/38:Irritating to respiratory system and skin . R41:Risk of serious damage to eyes. R36/37/38:Irritating to eyes, respiratory system and skin . R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
Safety Phrases S26-S39
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 29183000

 Synthetic Route

 Customs

HS Code 2918300090
Summary 2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Articles74

More Articles
Urinary metabolic fingerprinting of mice with diet-induced metabolic derangements by parallel dual secondary column-dual detection two-dimensional comprehensive gas chromatography.

J. Chromatogr. A. 1361 , 265-76, (2014)

This study investigates the potential of a parallel dual secondary column-dual detection two-dimensional comprehensive GC platform (GC×2GC-MS/FID) for metabolic profiling and fingerprinting of mouse u...

Physiology and pathophysiology of organic acids in cerebrospinal fluid.

J. Inherit. Metab. Dis. 16(4) , 648-69, (1993)

Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarbo...

Age-related reference values for urinary organic acids in a healthy Turkish pediatric population.

Clin. Chem. 40(6) , 862-6, (1994)

Organic acid concentrations were quantified by gas chromatography and the individual acids identified by mass spectrometry in urine specimens from a healthy Turkish pediatric population of ages 2 days...

 Synonyms

2-oxopentanedionic acid
ketoglutaric acid
EINECS 206-330-3
α-Oxoglutaric acid
FEMA 3891
Pentanedioic acid, 2-oxo- (9CI)
α-Oxopentanedioic acid
α-Ketoglutaric acid
A-KETOGLUTARIC ACID
2-Oxo-Glutaric Acid
2-Oxoglutaric acid,2-Oxopentanedioic acid
2-Oxoglutaric Acid
MFCD00004165
OXOGLUTARIC ACID
KETO-GLU
Pentanedioic acid, 2-oxo-
2-Ketoglutaric acid
2-Oxopentanedioic acid
Glutaric acid, 2-oxo- (8CI)
α-keto-Glutaric acid
Glutaric acid, 2-oxo-
2-Oxo-1,5-pentanedioic acid
Alphaketoglutaric acid
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