5-hydroxymethylfurfural

Modify Date: 2024-01-02 12:18:49

5-hydroxymethylfurfural Structure
5-hydroxymethylfurfural structure
Common Name 5-hydroxymethylfurfural
CAS Number 67-47-0 Molecular Weight 126.110
Density 1.3±0.1 g/cm3 Boiling Point 291.5±30.0 °C at 760 mmHg
Molecular Formula C6H6O3 Melting Point 28-34 °C(lit.)
MSDS Chinese USA Flash Point 79.4±0.0 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of 5-hydroxymethylfurfural


5-(Hydroxymethyl)furan-2-carbaldehyde, derived from lignocellulosic biomass, inhibits yeast growth and fermentation as stressors.

 Names

Name 5-hydroxymethylfurfural
Synonym More Synonyms

 5-hydroxymethylfurfural Biological Activity

Description 5-(Hydroxymethyl)furan-2-carbaldehyde, derived from lignocellulosic biomass, inhibits yeast growth and fermentation as stressors.
Related Catalog
Target

Yeast[1].

In Vitro It is found that furfural and HMF cause the attenuation of bulk translation activity and the assembly of cytoplasmic mRNP granules in Saccharomyces cerevisiae. Notably, a combination of furfural and HMF induce the remarkable repression of translation initiation and SG formation. Furfural and HMF can induce the formation of cytoplasmic mRNP granules, HMF also causes a gradual reduction in the polysome fraction and a concomitant increase in the 80S monosome fraction[1].
References

[1]. Iwaki A, et al. Biomass conversion inhibitors furfural and 5-hydroxymethylfurfural induce formation of messenger RNP granules and attenuate translation activity in Saccharomyces cerevisiae. Appl Environ Microbiol. 2013 Mar;79(5):1661-7.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 291.5±30.0 °C at 760 mmHg
Melting Point 28-34 °C(lit.)
Molecular Formula C6H6O3
Molecular Weight 126.110
Flash Point 79.4±0.0 °C
Exact Mass 126.031693
PSA 50.44000
LogP -0.45
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.563
Storage condition 2-8°C
Stability Light Sensitive, Very Hygroscopic

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LT7031100
CHEMICAL NAME :
2-Furaldehyde, 5-(hydroxymethyl)-
CAS REGISTRY NUMBER :
67-47-0
BEILSTEIN REFERENCE NO. :
0110889
LAST UPDATED :
199712
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C6-H6-O3
MOLECULAR WEIGHT :
126.12
WISWESSER LINE NOTATION :
T5OJ BVH E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
2 gm/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 227,117,1989

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P280-P304 + P340 + P312-P305 + P351 + P338-P337 + P313
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36-S24/25
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS LT7031100
Packaging Group III
HS Code 2932190090

 Synthetic Route

 Customs

HS Code 2932190090
Summary 2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

 Articles87

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 Synonyms

HMF
EINECS 200-654-9
5-(Hydroxymethyl)furan-2-carboxaldehyde
T5OJ BVH E1Q
5-(Hydroxymethyl)-2-furancarboxaldehyde
5-(Hydroxymethyl)furan-2-carbaldehyde
Aes-103
5-(Hydroxymethyl)furfural
5-Hydroxymethylfurfural
2-Furancarboxaldehyde, 5-(hydroxymethyl)-
MFCD00003234
2-furaldehyde, 5-(hydroxymethyl)-
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