D(-)-Glutamic acid

Modify Date: 2024-01-02 10:37:46

D(-)-Glutamic acid Structure
D(-)-Glutamic acid structure
 Common Name D(-)-Glutamic acid
CAS Number 6893-26-1 Molecular Weight 147.129
Density 1.4±0.1 g/cm3 Boiling Point 333.8±32.0 °C at 760 mmHg
Molecular Formula C5H9NO4 Melting Point 200-202ºC
MSDS Chinese USA Flash Point 155.7±25.1 °C

 Use of D(-)-Glutamic acid


D-glutamic acid, an enantiomer of L- glutamic acid, is widely used in pharmaceuticals and foods.

 Names

Name D-glutamic acid
Synonym More Synonyms

 D(-)-Glutamic acid Biological Activity

Description D-glutamic acid, an enantiomer of L- glutamic acid, is widely used in pharmaceuticals and foods.
Related Catalog
In Vitro Various d-amino acids, such as D-serine, D-aspartic acid (D-Asp), and D-glutamic acid (D-Glu) are widely found in mammals including human beings and they are now thought to be the candidates of novel physiologically active substances and/or biomarkers[1]. D-[Asp/Glu] (4 mg/mL) inhibits IgE binding (75%) to peanuts while D-Glu, D-Asp has no inhibitory effect. IgE is specific for D-[Asp/Glu] and may have the potential for removing IgE or reducing IgE binding to peanut allergens[2].
In Vivo D-glutamic acid is currently paid attention as a modulator of neuronal transmission and hormonal secretion. It is metabolized only by D-aspartate oxidase in mammals[1]. After intraperitoneal injection, L-glutamate is catabolized via a-ketoglutarate, whereas D-glutamate is converted to n-pyrrolidone carboxylic acid. Carbon 2 of both D- and L-glutamate is converted in the cecum to the methyl carbon of acetate. Both rat liver and kidney catalyze the conversion of D-glutamic acid to n-pyrrolidone carboxylic acid[3].
Animal Admin Rats: Male albino rats are given injections of L- or D-glutamic acid-2-C14, DL-glutamic acid-5-C14, or D-glutamic acid-5-C14. Injections by stomach tube or into the cecum are performed while the animals are under ether anesthesia. After the rats are killed, the “carcass” and liver glutamic acids are isolated, degraded, and assayed for radioactivity. “Carcass” refers to the entire animal, except liver, including the ished gastrointestinal tract[3].
References

[1]. Han H, et al. Changes in D-aspartic acid and D-glutamic acid levels in the tissues and physiological fluids of mice with various D-aspartate oxidase activities. J Pharm Biomed Anal. 2015 Dec 10;116:47-52.

[2]. Chung SY, et al. IgE binding to peanut allergens is inhibited by combined D-aspartic and D-glutamic acids. Food Chem. 2015 Jan 1;166:248-53.

[3]. Wilson W, et al. The metabolism of D- and L- glutamic acid in the rat. J Biol Chem. 1961 Feb;236:365-9.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 333.8±32.0 °C at 760 mmHg
Melting Point 200-202ºC
Molecular Formula C5H9NO4
Molecular Weight 147.129
Flash Point 155.7±25.1 °C
Exact Mass 147.053162
PSA 100.62000
LogP -1.43
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.522

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2918990090

 Synthetic Route

 Customs

HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

 Articles189

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 Synonyms

H-D-Glu-OH
Glutamic acid, D-
MFCD00063112
D(-)-Glutamic acid
glutamic acid D-form
EINECS 230-000-8
δ-Glutamic acid
hydrogen D-glutamate
d-Glu
(R)-(-)-GLUTAMIC ACID
R-(-)-Glutamic acid
(2R)-2-aminopentanedioic acid
D-Glutamic acid
D(-)-Glutamicacid
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