squalamine lactate

Modify Date: 2024-01-12 10:21:05

squalamine lactate Structure
squalamine lactate structure
Common Name squalamine lactate
CAS Number 320725-47-1 Molecular Weight 736.055
Density N/A Boiling Point N/A
Molecular Formula C37H71N3O8S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of squalamine lactate


Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration.

 Names

Name 1-(Diphenylmethyl)hydrazine hydrochloride
Synonym More Synonyms

 squalamine lactate Biological Activity

Description Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration.
Related Catalog
In Vitro Squalamine lactate has a more generalized effect on the cellular signaling cascade that is common to both VEGF and other growth factors[1]. Squalamine blocks the action of VEGF and integrin expression, thereby inhibiting angiogenesis, when bound to calmodulin[2].
In Vivo Squalamine is ineffective when administered intravitreally and therefore requires intravenous dosing. However, systemic dosing has yielded promising results in rats as well as humans[2].
References

[1]. Hussain RM, et al. Emerging vascular endothelial growth factor antagonists to treat neovascular age-related macular degeneration. Expert Opin Emerg Drugs. 2017 Sep;22(3):235-246.

[2]. Emerson MV, et al. Current and emerging therapies for the treatment of age-related macular degeneration. Clin Ophthalmol. 2008 Jun;2(2):377-88.

 Chemical & Physical Properties

Molecular Formula C37H71N3O8S
Molecular Weight 736.055
Exact Mass 735.506775
Storage condition -20°C

 Synonyms

(2S)-2-Hydroxypropanoic acid - (3β,5α,7α,24R)-3-({3-[(4-aminobutyl)amino]propyl}amino)-7-hydroxycholestan-24-yl hydrogen sulfate hydrate (1:1:1)
squalamine lactate