320725-47-1

320725-47-1 structure

Name: squalamine lactate
Chemical Name: 1-(Diphenylmethyl)hydrazine hydrochloride
CAS Number: 320725-47-1
Molecular Formula: C₃₇H₇₁N₃O₈S
Molecular Weight: 736.055
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-12-29 10:41:30
Modify Date: 2024-01-12 10:21:05
Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration.

Name	1-(Diphenylmethyl)hydrazine hydrochloride
Synonyms	(2S)-2-Hydroxypropanoic acid - (3β,5α,7α,24R)-3-({3-[(4-aminobutyl)amino]propyl}amino)-7-hydroxycholestan-24-yl hydrogen sulfate hydrate (1:1:1) squalamine lactate

Description	Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Natural Products >> Others Research Areas >> Cardiovascular Disease Research Areas >> Infection
In Vitro	Squalamine lactate has a more generalized effect on the cellular signaling cascade that is common to both VEGF and other growth factors[1]. Squalamine blocks the action of VEGF and integrin expression, thereby inhibiting angiogenesis, when bound to calmodulin[2].
In Vivo	Squalamine is ineffective when administered intravitreally and therefore requires intravenous dosing. However, systemic dosing has yielded promising results in rats as well as humans[2].
References	[1]. Hussain RM, et al. Emerging vascular endothelial growth factor antagonists to treat neovascular age-related macular degeneration. Expert Opin Emerg Drugs. 2017 Sep;22(3):235-246. [2]. Emerson MV, et al. Current and emerging therapies for the treatment of age-related macular degeneration. Clin Ophthalmol. 2008 Jun;2(2):377-88.