L-Ornithine L-aspartate salt

Modify Date: 2024-01-02 18:28:16

L-Ornithine L-aspartate salt Structure
L-Ornithine L-aspartate salt structure
Common Name L-Ornithine L-aspartate salt
CAS Number 3230-94-2 Molecular Weight 265.264
Density N/A Boiling Point 308.7ºC at 760 mmHg
Molecular Formula C9H19N3O6 Melting Point N/A
MSDS Chinese USA Flash Point 140.5ºC

 Use of L-Ornithine L-aspartate salt


L-Ornithine L-aspartate is a stable salt of two natural nonessential L-amino acids: ornithine and aspartic acid. L-Ornithine L-aspartate lowers blood ammonia concentration and to eliminate symptoms of hepatic encephalopathy associated with liver cirrhosis[1].

 Names

Name (2S)-2-aminobutanedioic acid,(2S)-2,5-diaminopentanoic acid
Synonym More Synonyms

 L-Ornithine L-aspartate salt Biological Activity

Description L-Ornithine L-aspartate is a stable salt of two natural nonessential L-amino acids: ornithine and aspartic acid. L-Ornithine L-aspartate lowers blood ammonia concentration and to eliminate symptoms of hepatic encephalopathy associated with liver cirrhosis[1].
Related Catalog
References

[1]. Sikorska H, et al. [Physiological functions of L-ornithine and L-aspartate in the body and the efficacy of administration of L-ornithine-L-aspartate in conditions of relative deficiency]. Pol Merkur Lekarski. 2010 Jun;28(168):490-5.

 Chemical & Physical Properties

Boiling Point 308.7ºC at 760 mmHg
Molecular Formula C9H19N3O6
Molecular Weight 265.264
Flash Point 140.5ºC
Exact Mass 265.127380
PSA 189.96000
LogP 0.11110
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CI9463000
CAS REGISTRY NUMBER :
3230-94-2
LAST UPDATED :
199701
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C5-H12-N2-O2.C4-H7-N-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85IPAE "Modern Pharmaceuticals of Japan, III," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1968 Volume(issue)/page/year: -,91,1968
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,164,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,164,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85IPAE "Modern Pharmaceuticals of Japan, III," Tokyo, Japan Pharmaceutical, Medical and Dental Supply Exporters' Assoc., 1968 Volume(issue)/page/year: -,91,1968

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S37/39
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS CI9463000
HS Code 2922499990

 Customs

HS Code 2922499990
Summary HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

 Articles26

More Articles
Modulation of neural activation following treatment of hepatic encephalopathy.

Neurology 80(11) , 1041-7, (2013)

To measure changes in psychometric state, neural activation, brain volume (BV), and cerebral metabolite concentrations during treatment of minimal hepatic encephalopathy.As proof of principle, 22 pati...

L-Ornithine-l-aspartate in the management of hepatic encephalopathy: a meta-analysis.

J. Gastroenterol. Hepatol. 24(1) , 9-14, (2009)

Hepatic encephalopathy continues to be a major clinical problem and the current decade has not witnessed major therapeutic breakthroughs in this area. L-ornithine-l-aspartate (LOLA) is not frequently ...

A double-blind, randomized, placebo-controlled trial of intravenous L-ornithine-L-aspartate on postural control in patients with cirrhosis.

Liver Int. 30(4) , 574-82, (2010)

Hepatic encephalopathy (HE) is a complication of liver disease. Several treatments have been introduced but only L-ornithine-L-aspartate (LOLA) shows proven efficacy. This double-blind, randomized, pl...

 Synonyms

L-Ornithine L-Aspartate Salt
L-Ornithine L-Aspartate
L-Ornithine-L-Aspartate
L-Aspartic acid - L-ornithine (1:1)
EINECS 221-772-7
L-OrnithineL-aspartatesalt
(S)-2,5-Diaminopentanoic acid L-aspartate salt
Hepa-Merz (TN)
L-Ornithin-L-aspartat
L-Aspartic acid, compd. with L-ornithine (1:1)
MFCD00058084
(S)-2,5-Diaminopentanoic acid compound with (S)-2-aminosuccinic acid
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