C-178
Modify Date: 2024-01-13 09:53:21
C-178 structure
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Common Name | C-178 | ||
|---|---|---|---|---|
| CAS Number | 329198-87-0 | Molecular Weight | 322.27 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H10N2O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of C-178C-178, a covalent inhibitor of STING, binds to Cys91, potently and selectively suppresses the STING responses elicited by distinct bona fide activators in mouse but not human. C-178 significantly reduces STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity. C-178 blocks palmitoylation (PMA)-induced clustering of STING; inhibits the CMA-induced phosphorylation of TBK1 (downstream protein kinase of STING)[1]. |
| Name | C-178 |
|---|
| Description | C-178, a covalent inhibitor of STING, binds to Cys91, potently and selectively suppresses the STING responses elicited by distinct bona fide activators in mouse but not human. C-178 significantly reduces STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity. C-178 blocks palmitoylation (PMA)-induced clustering of STING; inhibits the CMA-induced phosphorylation of TBK1 (downstream protein kinase of STING)[1]. |
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| Related Catalog | |
| Target |
STING[1] |
| References |
| Molecular Formula | C17H10N2O5 |
|---|---|
| Molecular Weight | 322.27 |