329198-87-0
329198-87-0 structure
- Name: C-178
- Chemical Name: C-178
- CAS Number: 329198-87-0
- Molecular Formula: C17H10N2O5
- Molecular Weight: 322.27
- Catalog: Signaling Pathways Immunology/Inflammation STING
- Create Date: 2019-10-09 13:41:29
- Modify Date: 2024-01-13 09:53:21
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C-178, a covalent inhibitor of STING, binds to Cys91, potently and selectively suppresses the STING responses elicited by distinct bona fide activators in mouse but not human. C-178 significantly reduces STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity. C-178 blocks palmitoylation (PMA)-induced clustering of STING; inhibits the CMA-induced phosphorylation of TBK1 (downstream protein kinase of STING)[1].
| Name | C-178 |
|---|
| Description | C-178, a covalent inhibitor of STING, binds to Cys91, potently and selectively suppresses the STING responses elicited by distinct bona fide activators in mouse but not human. C-178 significantly reduces STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity. C-178 blocks palmitoylation (PMA)-induced clustering of STING; inhibits the CMA-induced phosphorylation of TBK1 (downstream protein kinase of STING)[1]. |
|---|---|
| Related Catalog | |
| Target |
STING[1] |
| References |
| Molecular Formula | C17H10N2O5 |
|---|---|
| Molecular Weight | 322.27 |