329198-87-0

329198-87-0 structure

Name: C-178
Chemical Name: C-178
CAS Number: 329198-87-0
Molecular Formula: C₁₇H₁₀N₂O₅
Molecular Weight: 322.27
Catalog: Signaling Pathways Immunology/Inflammation STING
Create Date: 2019-10-09 13:41:29
Modify Date: 2024-01-13 09:53:21
C-178, a covalent inhibitor of STING, binds to Cys91, potently and selectively suppresses the STING responses elicited by distinct bona fide activators in mouse but not human. C-178 significantly reduces STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity. C-178 blocks palmitoylation (PMA)-induced clustering of STING; inhibits the CMA-induced phosphorylation of TBK1 (downstream protein kinase of STING)[1].

Name	C-178

Description	C-178, a covalent inhibitor of STING, binds to Cys91, potently and selectively suppresses the STING responses elicited by distinct bona fide activators in mouse but not human. C-178 significantly reduces STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity. C-178 blocks palmitoylation (PMA)-induced clustering of STING; inhibits the CMA-induced phosphorylation of TBK1 (downstream protein kinase of STING)[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> STING
Target	STING[1]
References	[1]. Haag SM, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273.

Molecular Formula	C₁₇H₁₀N₂O₅
Molecular Weight	322.27