TN-16

Modify Date: 2024-01-10 07:09:27

TN-16 structure	Common Name	TN-16
	CAS Number	33016-12-5	Molecular Weight	306.35800
	Density	1.249g/cm3	Boiling Point	532.7ºC at 760 mmHg
	Molecular Formula	C₁₉H₁₈N₂O₂	Melting Point	182-185 °C
	MSDS	Chinese USA	Flash Point	195.5ºC
	Symbol	GHS07, GHS09	Signal Word	Warning

Use of TN-16

TN-16 is a potent inhibitor of microtubule polymerization with IC50 of 0.4-1.7 µM[1].

Name	tn-16
Synonym	More Synonyms

Description	TN-16 is a potent inhibitor of microtubule polymerization with IC50 of 0.4-1.7 µM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
References	[1]. Arai T. Inhibition of microtubule assembly in vitro by TN-16, a synthetic antitumor drug. FEBS Lett. 1983 May 8;155(2):273-6.

Density	1.249g/cm3
Boiling Point	532.7ºC at 760 mmHg
Melting Point	182-185 °C
Molecular Formula	C₁₉H₁₈N₂O₂
Molecular Weight	306.35800
Flash Point	195.5ºC
Exact Mass	306.13700
PSA	58.20000
LogP	3.08450
Index of Refraction	1.648
Storage condition	2-8℃

TN-16 MSDS(Chinese)

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H317-H400
Precautionary Statements	P273-P280
Hazard Codes	Xi
Risk Phrases	43-50/53
Safety Phrases	36/37-60-61
RIDADR	UN 3077 9 / PGIII

CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly.

J. Cell Sci. 128 , 4572-87, (2015)

Although it is generally accepted that chromatin containing the histone H3 variant CENP-A is an epigenetic mark maintaining centromere identity, the pathways leading to the formation and maintenance o...

Inhibition of microtubule assembly in vitro by TN-16, a synthetic antitumor drug.

FEBS Lett. 155(2) , 273-6, (1983)

An antitumor drug, 3-(1-anilinoethylidene)-5-benzylpyrrolidine-2,4-dione (TN-16) inhibited the assembly of porcine brain microtubules in vitro. The assembly induced by taxol was also suppressed by the...

Localization of Fas ligand in cytoplasmic granules of CD8+ cytotoxic T lymphocytes and natural killer cells: participation of Fas ligand in granule exocytosis model of cytotoxicity.

Biochem. Biophys. Res. Commun. 296(2) , 328-36, (2002)

Fas ligand (FasL) has been implicated in cytotoxic T lymphocyte (CTL)- and natural killer (NK) cell-mediated cytotoxicity. In the present study, we investigated the localization of FasL in murine CTL ...

2,3`-ANHYDROTHYMIDINE-D3

3-[1-(Phenylamino)ethylidene]-5-(phenylmethyl)-2,4-pyrrolidinedione