ML-SA1

Modify Date: 2024-01-10 07:44:43

ML-SA1 structure	Common Name	ML-SA1
	CAS Number	332382-54-4	Molecular Weight	362.42200
	Density	1.226±0.06 g/cm3	Boiling Point	546.7±43.0 °C
	Molecular Formula	C₂₂H₂₂N₂O₃	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS06, GHS09	Signal Word	Danger

Use of ML-SA1

ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral[1].

Name	2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydro-1(2H)-quinolinyl)ethyl]-1 H-isoindole-1,3(2H)-dione
Synonym	More Synonyms

Description	ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Infection
Target	IC50: 8.3 μM (DENV2)[1]. IC50: 52.99 μM (ZIKV)[1]
In Vitro	ML-SA1 (25 μM; 0~14 hours; A549 cells) possibly affects the entry of DENV2 into host cells[1]. ML-SA1 (0~200 μM; A549 cells) shows that there is no cytotoxicity to the cell line observed, even at concentrations up to 200 μM. ML-SA1 (0~50 μM; A549 cells) significantly suppresses DENV2 at the RNA levels and the IC50 is 8.93 μM[1].ML-SA1 results in a dose-dependent decrease in ZIKV in A549 cells at both the RNA and protein levels, and the IC50 value of ML-SA1 against ZIKV RNA is 52.99 μM. ML-SA1, as an activator of TRPMLs, appears to be a potent inhibitor of DENV2 and ZIKV in vitro. ML-SA1 promotes lysosomal acidification and protease activity to inhibit viral infection. ML-SA1 can induce autophagy in Huh7 cells or A549 cells[1]. Western Blot Analysis[1] Cell Line: A549 cells Concentration: 25 μM Incubation Time: 0~14 hours Result: Possibly affected the entry of DENV2 into host cells.
References	[1]. Xia Z, et al. ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity. Antiviral Res. 2020;182:104922.

Density	1.226±0.06 g/cm3
Boiling Point	546.7±43.0 °C
Molecular Formula	C₂₂H₂₂N₂O₃
Molecular Weight	362.42200
Exact Mass	362.16300
PSA	57.69000
LogP	3.60450
Appearance of Characters	white to beige
Storage condition	2-8°C
Water Solubility	DMSO: soluble5mg/mL, clear (warmed)

ML-SA1 MSDS(Chinese)

Symbol	GHS06, GHS09
Signal Word	Danger
Hazard Statements	H301-H410
Precautionary Statements	P273-P301 + P310-P501
Hazard Codes	T
Risk Phrases	25-50/53
Safety Phrases	60-61
RIDADR	UN 2811 6.1 / PGIII
WGK Germany	3
HS Code	2933499090

HS Code	2933499090
Summary	2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%