ML-SA1
Modify Date: 2024-01-10 07:44:43
ML-SA1 structure
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Common Name | ML-SA1 | ||
|---|---|---|---|---|
| CAS Number | 332382-54-4 | Molecular Weight | 362.42200 | |
| Density | 1.226±0.06 g/cm3 | Boiling Point | 546.7±43.0 °C | |
| Molecular Formula | C22H22N2O3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS06, GHS09 |
Signal Word | Danger | |
Use of ML-SA1ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral[1]. |
| Name | 2-[2-Oxo-2-(2,2,4-trimethyl-3,4-dihydro-1(2H)-quinolinyl)ethyl]-1 H-isoindole-1,3(2H)-dione |
|---|---|
| Synonym | More Synonyms |
| Description | ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral[1]. |
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| Related Catalog | |
| Target |
IC50: 8.3 μM (DENV2)[1]. IC50: 52.99 μM (ZIKV)[1] |
| In Vitro | ML-SA1 (25 μM; 0~14 hours; A549 cells) possibly affects the entry of DENV2 into host cells[1]. ML-SA1 (0~200 μM; A549 cells) shows that there is no cytotoxicity to the cell line observed, even at concentrations up to 200 μM. ML-SA1 (0~50 μM; A549 cells) significantly suppresses DENV2 at the RNA levels and the IC50 is 8.93 μM[1].ML-SA1 results in a dose-dependent decrease in ZIKV in A549 cells at both the RNA and protein levels, and the IC50 value of ML-SA1 against ZIKV RNA is 52.99 μM. ML-SA1, as an activator of TRPMLs, appears to be a potent inhibitor of DENV2 and ZIKV in vitro. ML-SA1 promotes lysosomal acidification and protease activity to inhibit viral infection. ML-SA1 can induce autophagy in Huh7 cells or A549 cells[1]. Western Blot Analysis[1] Cell Line: A549 cells Concentration: 25 μM Incubation Time: 0~14 hours Result: Possibly affected the entry of DENV2 into host cells. |
| References |
| Density | 1.226±0.06 g/cm3 |
|---|---|
| Boiling Point | 546.7±43.0 °C |
| Molecular Formula | C22H22N2O3 |
| Molecular Weight | 362.42200 |
| Exact Mass | 362.16300 |
| PSA | 57.69000 |
| LogP | 3.60450 |
| Appearance of Characters | white to beige |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: soluble5mg/mL, clear (warmed) |
| Symbol |
GHS06, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H410 |
| Precautionary Statements | P273-P301 + P310-P501 |
| Hazard Codes | T |
| Risk Phrases | 25-50/53 |
| Safety Phrases | 60-61 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| HS Code | 2933499090 |
| HS Code | 2933499090 |
|---|---|
| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| ML-SA1 |