Chelerythrine

Modify Date: 2024-01-02 08:09:18

Chelerythrine Structure
Chelerythrine structure
 Common Name Chelerythrine
CAS Number 34316-15-9 Molecular Weight 348.371
Density N/A Boiling Point N/A
Molecular Formula C21H18ClNO4 Melting Point 195-205ºC
MSDS N/A Flash Point N/A

 Use of Chelerythrine


Chelerythrine is a natural alkaloid, acts as a potent and selective Ca2+/phospholopid-dependent PKC antagonist, with an IC50 of 0.7 μM[1]. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity[2].

 Names

Name chelerythrine
Synonym More Synonyms

 Chelerythrine Biological Activity

Description Chelerythrine is a natural alkaloid, acts as a potent and selective Ca2+/phospholopid-dependent PKC antagonist, with an IC50 of 0.7 μM[1]. Chelerythrine has antitumor, antidiabetic and anti-inflammatory activity[2].
Related Catalog
Target

PKC:0.7 μM (IC50)

References

[1]. Herbert JM, et al. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 1990 Nov 15;172(3):993-9.

[2]. Shi B, et al. Protein kinase C inhibitor chelerythrine attenuates partial unilateral ureteral obstruction induced kidney injury in neonatal rats. Life Sci. 2019 Jan 1;216:85-91.

 Chemical & Physical Properties

Melting Point 195-205ºC
Molecular Formula C21H18ClNO4
Molecular Weight 348.371
Exact Mass 348.123047
PSA 40.80000
LogP 0.72060
Storage condition Desiccate at -20°C

 Safety Information

Hazard Codes Xn:Harmful;
Risk Phrases R20/21/22
Safety Phrases S36/37
HS Code 2933990090

 Synthetic Route

allocryptopine N-oxide structure

allocryptopine ...

CAS#:87264-52-6

~2%

Chelerythrine Structure

Chelerythrine

CAS#:34316-15-9

3,4-dimethoxy-7-methyl-5,8,9,16-tetrahydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-e]benzo[i][1]oxa[2]azacycloundecin-15(7H)-one structure

3,4-dimethoxy-7...

CAS#:87264-54-8

Literature: Heterocycles, , vol. 20, # 8 p. 1535 - 1539

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

[1,3]Benzodioxolo[5,6-c]phenanthridinium, 1,2-dimethoxy-12-methyl-
1,2-Dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium
Cheleritrine
MFCD00060717
Chelerythrine
Chelerythrin-Kation
Chelerythrin
Chelerythrine chloride
1,2-Dimethoxy-12-methyl[1,3]dioxolo[4,5]benzo[1,2-c]phenanthridin-12-ium
Broussonpapyrine
Chelerythrin chlorid
EINECS 251-930-0
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Related Compounds: More...
Chelerythrine
478-03-5
y-Chelerythrine
2447-54-3
ψ-chelerythrine
117-00-0
Oxychelerythrine
28342-33-8
chelerythrine (c1)
6271-33-6
Chelerythrine Ψ-cyanid
5138-09-0
Chelerythrine chloride
3895-92-9
Sanguinarine chloride mixt. with chelerythrine chloride
112025-60-2
Chemsrc provides Chelerythrine(CAS#:34316-15-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Chelerythrine are included as well.>> amp version: Chelerythrine

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