4′-Demethylnobiletin

Modify Date: 2024-01-19 13:05:46

4′-Demethylnobiletin structure	Common Name	4′-Demethylnobiletin
	CAS Number	34810-62-3	Molecular Weight	388.36800
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₀O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 4′-Demethylnobiletin

4′-Demethylnobiletin is a bioactive metabolite that activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and reverses memory impairment associated with NMDA receptor antagonism by stimulating ERK signaling[1].

Name	4'-demethylnobiletin
Synonym	More Synonyms

Description	4′-Demethylnobiletin is a bioactive metabolite that activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and reverses memory impairment associated with NMDA receptor antagonism by stimulating ERK signaling[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Signaling Pathways >> Stem Cell/Wnt >> PKA Signaling Pathways >> MAPK/ERK Pathway >> ERK Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Stem Cell/Wnt >> ERK
In Vitro	4′-Demethylnobiletin(1-100 μM, 0-60 min) 可以以时间和浓度依赖性的方式激活大鼠海马神经元中 ERK 和 CREB 的磷酸化，并以 PKA/MEK/ERK 途径依赖的方式，同时也可以通过激活 PKA/MEK/ERK 依赖信号通路刺激 CRE 介导的转录[1]。
In Vivo	4′-Demethylnobiletin (10 or 50 mg/kg, ip, once daily for seven consecutive days)在雄性 ddY 小鼠中可以剂量依赖性地逆转了 MK-801 诱导的学习障碍，而不影响小鼠的活动能力。其中用 MK-801 处理的小鼠比对照组小鼠表现出更少的冻结，并诱导小鼠的海马体中的 ERK 学习激活抑制，而 4′-Demethylnobiletin 也可以逆转该行为[1]。 4′-Demethylnobiletin (10 or 50 mg/kg, ip, once daily for seven consecutive days)可以逆转 MK-801 对海马神经元中 NMDA 刺激的 ERK 和 PKA 底物磷酸化的抑制[1]。
References	[1]. Md Al Rahim, et al. 4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade. Biochemistry. 2009 Aug 18;48(32):7713-21.