Norgestimate

Modify Date: 2024-01-02 10:38:08

Norgestimate Structure
Norgestimate structure
 Common Name Norgestimate
CAS Number 35189-28-7 Molecular Weight 369.497
Density 1.2±0.1 g/cm3 Boiling Point 497.9±45.0 °C at 760 mmHg
Molecular Formula C23H31NO3 Melting Point 216ºC
MSDS Chinese USA Flash Point 254.9±28.7 °C
Symbol GHS07 GHS08
GHS07, GHS08		 Signal Word Warning

 Use of Norgestimate


Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive[1][2].

 Names

Name norgestimate
Synonym More Synonyms

 Norgestimate Biological Activity

Description Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive[1][2].
Related Catalog
In Vitro Norgestimate is converted to at least two active metabolites: levonorgestrel 3-oxime (deacetylated norgestimate; norelgestromin) and levonorgestrel[1].
References

[1]. Stanczyk FZ, et al. All progestins are not created equal. Steroids. 2003 Nov;68(10-13):879-90.

[2]. Phillips A, et al. Preclinical evaluation of norgestimate, a progestin with minimal androgenic activity. Am J Obstet Gynecol. 1992 Oct;167(4 Pt 2):1191-6.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 497.9±45.0 °C at 760 mmHg
Melting Point 216ºC
Molecular Formula C23H31NO3
Molecular Weight 369.497
Flash Point 254.9±28.7 °C
Exact Mass 369.230408
PSA 58.89000
LogP 5.00
Vapour Pressure 0.0±2.9 mmHg at 25°C
Index of Refraction 1.611

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
JF7976000
CHEMICAL NAME :
18,19-Dinorpregn-4-en-20-yn-3-one, 17-(acetyloxy)-13-ethyl-, 3-oxime, (17-alpha)-
CAS REGISTRY NUMBER :
35189-28-7
LAST UPDATED :
198910
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C23-H31-N-O3
MOLECULAR WEIGHT :
369.55

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1 mg/kg
SEX/DURATION :
female 2 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970- Volume(issue)/page/year: 16,541,1977

 Safety Information

Symbol GHS07 GHS08
GHS07, GHS08
Signal Word Warning
Hazard Statements H302-H315-H319-H361fd
Precautionary Statements P281-P305 + P351 + P338
Hazard Codes Xn
Risk Phrases 63-22-36/38-62
Safety Phrases 26-36/37
RIDADR NONH for all modes of transport
RTECS JF7976000

 Synthetic Route

(8R,9S,10R,13S,14S,17R)-13-Ethyl-17-ethynyl-3-oxo-2,3,6,7,8,9,10, 11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-1 7-yl acetate (non-preferred name) structure

(8R,9S,10R,13S,...

CAS#:13732-69-9

~85%

Norgestimate Structure

Norgestimate

CAS#:35189-28-7

Literature: RICHTER GEDEON VEGYESZETI GYAR R.T. Patent: WO2005/868 A1, 2005 ; Location in patent: Page/Page column 5 ;

 Precursor & DownStream

Precursor  1

DownStream  0

 Articles42

More Articles
Types of combined oral contraceptives used by US women.

Contraception 86(6) , 659-65, (2012)

We sought to estimate the prevalence of types of combined oral contraceptives (COCs) used among US women.We analyzed interview-collected data from 12,279 women aged 15-44 years participating in the Na...

Mechanosensitive ATP release from hemichannels and Ca²⁺ influx through TRPC6 accelerate wound closure in keratinocytes.

J. Cell Sci. 127(Pt 19) , 4159-71, (2014)

The study aimed to investigate the effect of inhibition of poly(ADP-ribose) polymerase-1 (PARP-1) activity on tau phosphorylation in HEK293/tau441 cells and its mechanism. HEK293/tau441 cells were tre...

Progestins in preventive hormone therapy. Including pharmacology of the new progestins, desogestrel, norgestimate, and gestodene: are there advantages?

Obstet. Gynecol. Clin. North Am. 21(2) , 299-319, (1994)

Clofarabine was the latest new drug to be approved, in 2004, for relapsed or refractory acute lymphoblastic leukaemia (ALL). To investigate its value in the frontline treatment of ALL we applied clofa...

 Synonyms

(3E,8R,9S,10R,13S,14S,17R)-13-Ethyl-17-ethynyl-3-(hydroxyimino)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate
(+)-13-Ethyl-17-hydroxy-18,19-dinor-17a-pregn-4-en-20-yn-3-one Oxime Acetate (Ester)
d-17beta-acetoxy-13beta-ethyl-17alpha-ethinyl-gon-4en-3-one oxime
dexnorgestrelacetime
Norgestimat
Norgestimate
NORGESTIMATE,USP STANDARD
levonorgestrel acetate 3-oxime
(3E,8R,9S,10R,13S,14S,17R)-17-Ethinyl-13-ethyl-3-(hydroxyimino)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ylacetat
acétate de (3E,8R,9S,10R,13S,14S,17R)-13-éthyl-17-éthynyl-3-(hydroxyimino)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tétradécahydro-1H-cyclopenta[a]phénanthrén-17-yle
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