Norgestimate-d6

Modify Date: 2024-01-13 19:10:46

Norgestimate-d6 Structure
Norgestimate-d6 structure
Common Name Norgestimate-d6
CAS Number 1263194-12-2 Molecular Weight 375.534
Density 1.2±0.1 g/cm3 Boiling Point 497.9±45.0 °C at 760 mmHg
Molecular Formula C23H25D6NO3 Melting Point N/A
MSDS N/A Flash Point 254.9±28.7 °C

 Use of Norgestimate-d6


Norgestimate D6 is the deuterium labeled Norgestimate. Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive[1][2].

 Names

Name Norgestimate-d6
Synonym More Synonyms

 Norgestimate-d6 Biological Activity

Description Norgestimate D6 is the deuterium labeled Norgestimate. Norgestimate, a synthetic progesterone analog, is an orally active progestin with highly selective progestational activity and minimal androgenicity. Norgestimate is used for an oral contraceptive[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Stanczyk FZ, et al. All progestins are not created equal. Steroids. 2003 Nov;68(10-13):879-90.

[3]. Phillips A, et al. Preclinical evaluation of norgestimate, a progestin with minimal androgenic activity. Am J Obstet Gynecol. 1992 Oct;167(4 Pt 2):1191-6.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 497.9±45.0 °C at 760 mmHg
Molecular Formula C23H25D6NO3
Molecular Weight 375.534
Flash Point 254.9±28.7 °C
Exact Mass 375.268066
LogP 5.00
Vapour Pressure 0.0±2.9 mmHg at 25°C
Index of Refraction 1.611

 Synonyms

NORGESTIMATE-D6
MFCD18385033
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