Kudinoside H

Modify Date: 2024-01-02 17:57:29

Kudinoside H structure	Common Name	Kudinoside H
	CAS Number	35286-58-9	Molecular Weight	766.955
	Density	1.35	Boiling Point	841.9±65.0 °C at 760 mmHg
	Molecular Formula	C₄₁H₆₆O₁₃	Melting Point	198-202ºC
	MSDS	N/A	Flash Point	247.2±27.8 °C

Use of Kudinoside H

Ziyuglycoside I isolated from S. officinalis root, has anti-wrinkle activity, and increases the expression of type I collagen. Ziyuglycoside I could be used as an active ingredient for cosmetics[1].Ziyuglycoside I triggers cell cycle arrest and apoptosis mediated by p53, it can be a potential drug candidate for treating triple-negative breast cancer (TNBC)[2].

Name	Ziyuglycoside I
Synonym	More Synonyms

Description	Ziyuglycoside I isolated from S. officinalis root, has anti-wrinkle activity, and increases the expression of type I collagen. Ziyuglycoside I could be used as an active ingredient for cosmetics[1].Ziyuglycoside I triggers cell cycle arrest and apoptosis mediated by p53, it can be a potential drug candidate for treating triple-negative breast cancer (TNBC)[2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Apoptosis >> MDM-2/p53
In Vitro	Ziyuglycoside I (5-160 µM; 24 hours) reveals a marked anti-proliferation activity with an IC50 value of 13.96 µM in MDA-MB-231 cells[2]. Ziyuglycoside I (5-20 µM; 24 hours) induces MDA-MB-231 cell apoptosis by increasing the percentage of apoptotic cells from 2.43% to 44.76% at 20 µM[2]. Ziyuglycoside I (5-20 µM; 24 hours) induces the cleavage of caspas-8, caspase-9, and caspase-3, up-regulates the pro-apoptotic protein Bax, and down-regulates anti-apoptotic protein Bal-2, dose-dependently reduces the level of mito-cyto c expression[2]. Cell Viability Assay[1] Cell Line: MDA-MB-231 cells Concentration: 5 µM, 10 µM, 20 µM, 40 µM, 80 µM, and 160 µM Incubation Time: 24 hours Result: Showed cytotoxicity on MDA-MB-231 cells. Cell Cycle Analysis[1] Cell Line: MDA-MB-231 cells Concentration: 5 µM, 10 µM, and 20 µM Incubation Time: 24 hours Result: Induced G2/M phase arrest and apoptosis on MDA-MB-231 Cells Western Blot Analysis[1] Cell Line: MDA-MB-231 cells Concentration: 5 µM, 10 µM, and 20 µM Incubation Time: 24 hours Result: Induced apoptosis in MDA-MB-231 Cells through Intrinsic and Extrinsic Pathways.
References	[1]. Kim YH, et al. Anti-wrinkle activity of ziyuglycoside I isolated from a Sanguisorba officinalis root extract and its application as a cosmeceutical ingredient. Biosci Biotechnol Biochem. 2008 Feb;72(2):303-11. Epub 2008 Feb 7. [2]. Zhu X, et al. Ziyuglycoside I Inhibits the Proliferation of MDA-MB-231 Breast Carcinoma Cells through Inducing p53-Mediated G2/M Cell Cycle Arrest and Intrinsic/Extrinsic Apoptosis. Int J Mol Sci. 2016 Nov 22;17(11). pii: E1903

Density	1.35
Boiling Point	841.9±65.0 °C at 760 mmHg
Melting Point	198-202ºC
Molecular Formula	C₄₁H₆₆O₁₃
Molecular Weight	766.955
Flash Point	247.2±27.8 °C
Exact Mass	766.450317
PSA	215.83000
LogP	6.59
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.610
Storage condition	2-8°C