THP-CH3-ethyl propionate

Modify Date: 2024-01-10 17:53:54

THP-CH3-ethyl propionate Structure
THP-CH3-ethyl propionate structure
Common Name THP-CH3-ethyl propionate
CAS Number 3539-40-0 Molecular Weight 202.24800
Density 1.05g/cm3 Boiling Point 292.7ºC at 760mmHg
Molecular Formula C10H18O4 Melting Point N/A
MSDS N/A Flash Point 125.6ºC

 Use of THP-CH3-ethyl propionate


THP-CH3-ethyl propionate is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name ethyl 2-(oxan-2-yloxy)propanoate
Synonym More Synonyms

 THP-CH3-ethyl propionate Biological Activity

Description THP-CH3-ethyl propionate is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.05g/cm3
Boiling Point 292.7ºC at 760mmHg
Molecular Formula C10H18O4
Molecular Weight 202.24800
Flash Point 125.6ºC
Exact Mass 202.12100
PSA 44.76000
LogP 1.48120
Index of Refraction 1.448

 Synthetic Route

~%

THP-CH3-ethyl propionate Structure

THP-CH3-ethyl p...

CAS#:3539-40-0

Literature: Daiichi Pharmaceutical Co., Ltd. Patent: US5136059 A1, 1992 ;

 Synonyms

Tetrahydropyranylethyllactat
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