CP-20961

Modify Date: 2024-01-09 11:44:29

CP-20961 Structure
CP-20961 structure
Common Name CP-20961
CAS Number 35607-20-6 Molecular Weight 667.18700
Density 0.892g/cm3 Boiling Point 717.6ºC at 760mmHg
Molecular Formula C43H90N2O2 Melting Point N/A
MSDS USA Flash Point 294.3ºC

 Use of CP-20961


CP-20961 is a potent synthetic non-immunogenic adjuvant that induces arthritis[1][2].

 Names

Name 2-[3-(dioctadecylamino)propyl-(2-hydroxyethyl)amino]ethanol
Synonym More Synonyms

 CP-20961 Biological Activity

Description CP-20961 is a potent synthetic non-immunogenic adjuvant that induces arthritis[1][2].
Related Catalog
In Vivo Avridine-induced arthritis is severe and long lasting in LEW and DA rats[2]. CP-20961 (10 mg/kg, i.v., once either 24, 48, or 72 hours post-burn) had no effect on survival after challenge with P. aeruginosa 96 hours post-burn[3]. Animal Model: Female, Hartley-derived guinea pigs, weighing 350 to 400 g[3]. Dosage: 10 mg/kg. Administration: IV once either 24, 48, or 72 hours post-burn. Result: Had no effect on survival after challenge with P. aeruginosa 96 hours post-burn.
References

[1]. Brun JG, et al. Effects of calprotectin in avridine-induced arthritis. APMIS. 1995 Mar;103(3):233-40.

[2]. Vingsbo C, et al. Avridine-induced arthritis in rats; a T cell-dependent chronic disease influenced both by MHC genes and by non-MHC genes. Clin Exp Immunol. 1995 Mar;99(3):359-63.

[3]. Stinnett JD, et al. Synthetic immunomodulators for prevention of fatal infections in a burned guinea pig model. Ann Surg. 1983 Jul;198(1):53-7.

 Chemical & Physical Properties

Density 0.892g/cm3
Boiling Point 717.6ºC at 760mmHg
Molecular Formula C43H90N2O2
Molecular Weight 667.18700
Flash Point 294.3ºC
Exact Mass 666.70000
PSA 46.94000
LogP 12.48810
Index of Refraction 1.478

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KK7243000
CHEMICAL NAME :
Ethanol, 2,2'-((3-(dioctadecylamino)propyl)imino)bis-
CAS REGISTRY NUMBER :
35607-20-6
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C43-H90-N2-O2
MOLECULAR WEIGHT :
667.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 3,498,1973

 Safety Information

RIDADR NONH for all modes of transport
RTECS KK7243000
HS Code 2922199090

 Customs

HS Code 2922199090
Summary 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles24

More Articles
Identification of arthritogenic adjuvants of self and foreign origin.

Scand. J. Immunol. 49(1) , 45-50, (1999)

The lack of defined triggers for human inflammatory joint diseases warrants efforts to identify candidate molecules. For this task, it may be an important lead that nonspecific activation of the immun...

A 71-kD heat shock protein (hsp) from Mycobacterium tuberculosis has modulatory effects on experimental rat arthritis.

Clin. Exp. Immunol. 103(1) , 77-82, (1996)

The effects of a mycobacterial 71-kD hsp antigen have been investigated for its ability to modulate arthritis in rats. Subcutaneous injection (base of tail) of increasing amounts of hsp71 from Mycobac...

Effect of the bacillus of Calmette-Guérin, Propionibacter acnes and avridine as immunomodulators in antirabies vaccination of mice using the Fuenzalida-Palacios mouse brain vaccine.

Vaccine 17(19) , 2446-52, (1999)

Using the laboratory mice, Fuenzalida-Palacios mouse brain human rabies vaccine was administered in groups of animals previously inoculated with rabies virus and then submitted to treatments with the ...

 Synonyms

cp-20,961
avridine
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