2,4-Thiazolidinedione,5-[(2-nitrophenyl)methylene]-

Modify Date: 2024-01-08 13:00:56

2,4-Thiazolidinedione,5-[(2-nitrophenyl)methylene]- Structure
2,4-Thiazolidinedione,5-[(2-nitrophenyl)methylene]- structure
Common Name 2,4-Thiazolidinedione,5-[(2-nitrophenyl)methylene]-
CAS Number 36140-65-5 Molecular Weight 250.23
Density 1.595g/cm3 Boiling Point N/A
Molecular Formula C10H6N2O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 2,4-Thiazolidinedione,5-[(2-nitrophenyl)methylene]-


5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione (Compound 4) has antimicrobial, anti-diabetic and antioxidant activities. 5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione inhibits B. subtilis, S. aureus, K. pneumonia, E. coli, and S. typhi with MICs of 4.5-9.9 μΜ/mL, and inhibits A. niger and C. albicans with MICs of 4.99 μΜ/mL[1].

 Names

Name 5-[(2-nitrophenyl)methylidene]-1,3-thiazolidine-2,4-dione
Synonym More Synonyms

  Biological Activity

Description 5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione (Compound 4) has antimicrobial, anti-diabetic and antioxidant activities. 5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione inhibits B. subtilis, S. aureus, K. pneumonia, E. coli, and S. typhi with MICs of 4.5-9.9 μΜ/mL, and inhibits A. niger and C. albicans with MICs of 4.99 μΜ/mL[1].
Related Catalog
References

[1]. Elkamhawy A, et al. Thiazolidine-2,4-dione-based irreversible allosteric IKK-β kinase inhibitors: Optimization into in vivo active anti-inflammatory agents. Eur J Med Chem. 2020 Feb 15;188:111955.  

 Chemical & Physical Properties

Density 1.595g/cm3
Molecular Formula C10H6N2O4S
Molecular Weight 250.23
Exact Mass 250.00500
PSA 117.29000
LogP 2.77070
Index of Refraction 1.732
Storage condition -20℃

 Safety Information

HS Code 2934999090

 Synthetic Route

~%

2,4-Thiazolidinedione,5-[(2-nitrophenyl)methylene]- Structure

2,4-Thiazolidin...

CAS#:36140-65-5

Literature: Taniyama et al. Yakugaku Zasshi, 1956 , vol. 76, p. 154,157 Chem.Abstr., 1956 , p. 13878 Full Text Show Details Tanasescu; Denes Chemische Berichte, 1957 , vol. 90, p. 495,497, 498 Chemische Berichte, 1958 , vol. 91, p. 1601,1603

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

5-(2-nitro-benzylidene)-thiazolidine-2,4-dione
5-[(2-nitrophenyl)methylidene]thiazolidine-2,4-dione
5-(2-Nitro-benzyliden)-thiazolidin-2,4-dion
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