Cyclo(L-Phe-L-Pro)

Modify Date: 2024-01-12 19:48:30

Cyclo(L-Phe-L-Pro) structure	Common Name	Cyclo(L-Phe-L-Pro)
	CAS Number	3705-26-8	Molecular Weight	244.289
	Density	1.3±0.1 g/cm3	Boiling Point	509.5±39.0 °C at 760 mmHg
	Molecular Formula	C₁₄H₁₆N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	262.0±27.1 °C

Use of Cyclo(L-Phe-L-Pro)

Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide[1]. Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation[2]. Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC50 of 24 µM in the DPPH assay[3].

Name	cyclo(-phe-pro)
Synonym	More Synonyms

Description	Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide[1]. Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation[2]. Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC50 of 24 µM in the DPPH assay[3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> IFNAR Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Research Areas >> Inflammation/Immunology
References	[1]. Katrin Ström, et al. Lactobacillus plantarum MiLAB 393 Produces the Antifungal Cyclic Dipeptides Cyclo(L-Phe-L-Pro) and Cyclo(L-Phe-trans-4-OH-L-Pro) and 3-Phenyllactic Acid. Appl Environ Microbiol. 2002 Sep;68(9):4322-7. [2]. Wooseong Lee, et al. Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity. Nat Commun. 2018 Apr 23;9(1):1606. [3]. Keyong Ho Lee, et al. Radioprotective effect of cyclo(L-phenylalanyl-L-prolyl) on irradiated rat lung. J Microbiol Biotechnol. 2008 Feb;18(2):369-76.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Immunology/Inflammation >> IFNAR

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Research Areas >> Inflammation/Immunology

References

[1]. Katrin Ström, et al. Lactobacillus plantarum MiLAB 393 Produces the Antifungal Cyclic Dipeptides Cyclo(L-Phe-L-Pro) and Cyclo(L-Phe-trans-4-OH-L-Pro) and 3-Phenyllactic Acid. Appl Environ Microbiol. 2002 Sep;68(9):4322-7.

[2]. Wooseong Lee, et al. Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity. Nat Commun. 2018 Apr 23;9(1):1606.

[3]. Keyong Ho Lee, et al. Radioprotective effect of cyclo(L-phenylalanyl-L-prolyl) on irradiated rat lung. J Microbiol Biotechnol. 2008 Feb;18(2):369-76.

Density	1.3±0.1 g/cm3
Boiling Point	509.5±39.0 °C at 760 mmHg
Molecular Formula	C₁₄H₁₆N₂O₂
Molecular Weight	244.289
Flash Point	262.0±27.1 °C
Exact Mass	244.121185
PSA	49.41000
LogP	-0.56
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.614
Storage condition	-15°C