Madrasin
Modify Date: 2024-01-04 20:07:36
Madrasin structure
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Common Name | Madrasin | ||
|---|---|---|---|---|
| CAS Number | 374913-63-0 | Molecular Weight | 311.339 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 567.2±42.0 °C at 760 mmHg | |
| Molecular Formula | C16H17N5O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 296.9±27.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of MadrasinMadrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin is cytotoxic at higher concentrations, although at lower concentrations it induces cell cycle arrest, promotes a specific reorganization of subnuclear protein localization, and modulates splicing of multiple pre-mRNAs in both HeLa and HEK293 cells. |
| Name | 2-[(7-Methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-4(1H)-pyrimidinone |
|---|---|
| Synonym | More Synonyms |
| Description | Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. Madrasin is cytotoxic at higher concentrations, although at lower concentrations it induces cell cycle arrest, promotes a specific reorganization of subnuclear protein localization, and modulates splicing of multiple pre-mRNAs in both HeLa and HEK293 cells. |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 567.2±42.0 °C at 760 mmHg |
| Molecular Formula | C16H17N5O2 |
| Molecular Weight | 311.339 |
| Flash Point | 296.9±27.9 °C |
| Exact Mass | 311.138214 |
| LogP | 1.91 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.671 |
| Storage condition | 2-8℃ |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P301 + P312 + P330 |
| RIDADR | NONH for all modes of transport |
| 2-[(7-methoxy-4-methylquinazolin-2-yl)amino]-5,6-dimethylpyrimidin-4(1H)-one |
| 4(1H)-Pyrimidinone, 2-[(7-methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl- |
| 2-[(7-Methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-4(1H)-pyrimidinone |
| Madrasin |