DQP 1105

Modify Date: 2024-01-24 14:01:14

DQP 1105 Structure
DQP 1105 structure
Common Name DQP 1105
CAS Number 380560-89-4 Molecular Weight 558.42300
Density N/A Boiling Point N/A
Molecular Formula C29H24BrN3O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DQP 1105


DQP-1105 is a potent noncompetitive NMDA receptor antagonist. DQP-1105 inhibits GluN2C- and GluN2D-containing receptors (IC50=7.0 and 2.7 μM, respectively). The IC50 values are at least 50-fold lower than those for recombinant GluN2A-, GluN2B-, GluA1-, or GluK2-containing receptors[1].

 Names

Name 4-[5-(4-Bromophenyl)-3-(6-methyl-2-oxo-4-phenyl-1,2-dihydro-3-qui nolinyl)-4,5-dihydro-1H-pyrazol-1-yl]-4-oxobutanoic acid

 DQP 1105 Biological Activity

Description DQP-1105 is a potent noncompetitive NMDA receptor antagonist. DQP-1105 inhibits GluN2C- and GluN2D-containing receptors (IC50=7.0 and 2.7 μM, respectively). The IC50 values are at least 50-fold lower than those for recombinant GluN2A-, GluN2B-, GluA1-, or GluK2-containing receptors[1].
Related Catalog
References

[1]. Acker TM, et al. Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators. Mol Pharmacol. 2011;80(5):782-795.

 Chemical & Physical Properties

Molecular Formula C29H24BrN3O4
Molecular Weight 558.42300
Exact Mass 557.09500
PSA 103.09000
LogP 5.59430
Storage condition -20°C
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