Z-Guggulsterone structure
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Common Name | Z-Guggulsterone | ||
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CAS Number | 39025-23-5 | Molecular Weight | 312.446 | |
Density | 1.1±0.1 g/cm3 | Boiling Point | 463.3±45.0 °C at 760 mmHg | |
Molecular Formula | C21H28O2 | Melting Point | 188-190° | |
MSDS | Chinese USA | Flash Point | 172.3±25.7 °C | |
Symbol |
GHS07 |
Signal Word | Warning |
Use of Z-GuggulsteroneZ-guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis[1]. |
Name | (Z)-Guggulsterone |
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Synonym | More Synonyms |
Description | Z-guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis[1]. |
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Related Catalog | |
Target |
VEGF-R2 Akt |
In Vitro | Z-guggulsterone (10, 20 μM; 24 or 48 hours) causes a decrease in the level of VEGF-R2 protein in HUVEC[1]. Western Blot Analysis[1] Cell Line: Vascular endothelial growth factor (VEGF) Concentration: 10, 20 μM Incubation Time: 24 or 48 hours Result: Caused a decrease in the level of VEGF-R2 protein in HUVEC. |
In Vivo | Z-guggulsterone (oral; 1 mg; 5 times/week) results in a statistically significantly decrease in tumor volume and wet tumor weight[1]. Animal Model: Male nude mice (5–6 weeks old) s.c. implanted with DU145 cell-containing Matrigel plugs Dosage: 1 mg Administration: Oral; 5 times/week Result: Resulted in a statistically significantly decrease in tumor volume and wet tumor weight. |
References |
Density | 1.1±0.1 g/cm3 |
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Boiling Point | 463.3±45.0 °C at 760 mmHg |
Melting Point | 188-190° |
Molecular Formula | C21H28O2 |
Molecular Weight | 312.446 |
Flash Point | 172.3±25.7 °C |
Exact Mass | 312.208923 |
PSA | 34.14000 |
LogP | 3.65 |
Vapour Pressure | 0.0±1.1 mmHg at 25°C |
Index of Refraction | 1.557 |
Storage condition | 2-8°C |
Precursor 1 | |
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DownStream 0 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
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Conformational dynamics of human FXR-LBD ligand interactions studied by hydrogen/deuterium exchange mass spectrometry: insights into the antagonism of the hypolipidemic agent Z-guggulsterone.
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Guggulsterone |
(17E)-Pregna-4,17-diene-3,16-dione |
(17Z)-Pregna-4,17(20)-diene-3,16-dione 4,17(20)-trans-Pregnadiene-3,16-dione |
UNII:9B259YE66O |
Pregna-4,17(20)-diene-3,16-dione, (17E)- |
(17E)-Pregna-4,17(20)-diene-3,16-dione |
Z-Guggulsterone,(Z)-Pregna-4,17(20)-diene-3,16-dione |
E-guggulsterone |
Pregna-4,17-diene-3,16-dione, (17E)- |
trans-Guggulsterone |
GUGGULSTERONE, (E)- |