39025-23-5
39025-23-5 structure
- Name: Z-Guggulsterone
- Chemical Name: (Z)-Guggulsterone
- CAS Number: 39025-23-5
- Molecular Formula: C21H28O2
- Molecular Weight: 312.446
- Catalog: Biochemical Plant extracts
- Create Date: 2018-09-05 11:10:03
- Modify Date: 2024-01-06 16:45:54
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Z-guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis[1].
| Name | (Z)-Guggulsterone |
|---|---|
| Synonyms |
Guggulsterone
(17E)-Pregna-4,17-diene-3,16-dione (17Z)-Pregna-4,17(20)-diene-3,16-dione 4,17(20)-trans-Pregnadiene-3,16-dione UNII:9B259YE66O Pregna-4,17(20)-diene-3,16-dione, (17E)- (17E)-Pregna-4,17(20)-diene-3,16-dione Z-Guggulsterone,(Z)-Pregna-4,17(20)-diene-3,16-dione E-guggulsterone Pregna-4,17-diene-3,16-dione, (17E)- trans-Guggulsterone GUGGULSTERONE, (E)- |
| Description | Z-guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis[1]. |
|---|---|
| Related Catalog | |
| Target |
VEGF-R2 Akt |
| In Vitro | Z-guggulsterone (10, 20 μM; 24 or 48 hours) causes a decrease in the level of VEGF-R2 protein in HUVEC[1]. Western Blot Analysis[1] Cell Line: Vascular endothelial growth factor (VEGF) Concentration: 10, 20 μM Incubation Time: 24 or 48 hours Result: Caused a decrease in the level of VEGF-R2 protein in HUVEC. |
| In Vivo | Z-guggulsterone (oral; 1 mg; 5 times/week) results in a statistically significantly decrease in tumor volume and wet tumor weight[1]. Animal Model: Male nude mice (5–6 weeks old) s.c. implanted with DU145 cell-containing Matrigel plugs Dosage: 1 mg Administration: Oral; 5 times/week Result: Resulted in a statistically significantly decrease in tumor volume and wet tumor weight. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 463.3±45.0 °C at 760 mmHg |
| Melting Point | 188-190° |
| Molecular Formula | C21H28O2 |
| Molecular Weight | 312.446 |
| Flash Point | 172.3±25.7 °C |
| Exact Mass | 312.208923 |
| PSA | 34.14000 |
| LogP | 3.65 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.557 |
| Storage condition | 2-8°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | R37 |
| Safety Phrases | S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| Precursor 1 | |
|---|---|
| DownStream 0 | |
