9-Methoxycamptothecine

Modify Date: 2024-01-02 15:52:12

9-Methoxycamptothecine structure	Common Name	9-Methoxycamptothecine
	CAS Number	39026-92-1	Molecular Weight	378.378
	Density	1.5±0.1 g/cm3	Boiling Point	773.1±60.0 °C at 760 mmHg
	Molecular Formula	C₂₁H₁₈N₂O₅	Melting Point	223-225 ºC
	MSDS	N/A	Flash Point	421.4±32.9 °C

Use of 9-Methoxycamptothecine

9-Methoxycamptothecin (MCPT), isolated from Nothapodytes foetida, has antitumor activities through topoisomerase inhibition. 9-Methoxycamptothecin (MCPT) induces strong G2/M arrest and apoptosis in cancer[1][2].

Name	9-Methoxycamptothecin
Synonym	More Synonyms

Description	9-Methoxycamptothecin (MCPT), isolated from Nothapodytes foetida, has antitumor activities through topoisomerase inhibition. 9-Methoxycamptothecin (MCPT) induces strong G2/M arrest and apoptosis in cancer[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
Target	Topoisomerase[1]. Apoptosis[2].
References	[1]. Liao N, et al. 9-methoxycamptothecin from Nothapodytes foetida induces apoptosis in murine sarcoma S180 cells. Z Naturforsch C. 2011 Sep-Oct;66(9-10):471-6. [2]. Wang H, et al. TNFα and Fas/FasL pathways are involved in 9-Methoxycamptothecin-induced apoptosis in cancer cells with oxidative stress and G2/M cell cycle arrest. Food Chem Toxicol. 2013 May;55:396-410.

Density	1.5±0.1 g/cm3
Boiling Point	773.1±60.0 °C at 760 mmHg
Melting Point	223-225 ºC
Molecular Formula	C₂₁H₁₈N₂O₅
Molecular Weight	378.378
Flash Point	421.4±32.9 °C
Exact Mass	378.121582
PSA	90.65000
LogP	2.00
Vapour Pressure	0.0±2.8 mmHg at 25°C
Index of Refraction	1.723
Storage condition	2-8°C
Water Solubility	Slightly soluble (2.7 g/L) (25 ºC)

rubitecan

CAS#:91421-42-0

9-Methoxycampto...

CAS#:39026-92-1

Literature: Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 17 p. 3865 - 3869

diazomethane

CAS#:186581-53-3

9-Hydroxycampto...

CAS#:67656-30-8

~94%

9-Methoxycampto...

CAS#:39026-92-1

Literature: Sawada; Matsuoka; Nokata; Nagata; Furuta; Yokokura; Miyasaka Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 12 p. 3183 - 3188

9-Aminocamptothecin

CAS#:91421-43-1

9-Methoxycampto...

CAS#:39026-92-1

Literature: Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 17 p. 3865 - 3869

Campathecin

CAS#:7689-03-4

9-Methoxycampto...

CAS#:39026-92-1

Literature: Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 17 p. 3865 - 3869

Precursor 5
CAS#:91421-42-0 rubitecan CAS#:186581-53-3 diazomethane CAS#:67656-30-8 9-Hydroxycampto... CAS#:91421-43-1 9-Aminocamptothecin
CAS#:7689-03-4 Campathecin
DownStream 0

1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-10-methoxy-, (4S)-

10-methoxycamptothecin

9-methoxycamtothecin

(4S)-4-Ethyl-4-hydroxy-10-methoxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

Camptothecin,9-methoxy

9-Methoxycamptothecine

Use of 9-Methoxycamptothecine

Names

9-Methoxycamptothecine Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms