Z-Sar-OH

Modify Date: 2024-01-02 16:45:15

Z-Sar-OH Structure
Z-Sar-OH structure
 Common Name Z-Sar-OH
CAS Number 39608-31-6 Molecular Weight 223.225
Density 1.3±0.1 g/cm3 Boiling Point 385.6±31.0 °C at 760 mmHg
Molecular Formula C11H13NO4 Melting Point 58-59ºC
MSDS USA Flash Point 187.0±24.8 °C

 Use of Z-Sar-OH


Z-Sar-OH is a Glycine (HY-Y0966) derivative[1].

 Names

Name 2-[methyl(phenylmethoxycarbonyl)amino]acetic acid
Synonym More Synonyms

 Z-Sar-OH Biological Activity

Description Z-Sar-OH is a Glycine (HY-Y0966) derivative[1].
Related Catalog
In Vitro Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].
References

[1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 385.6±31.0 °C at 760 mmHg
Melting Point 58-59ºC
Molecular Formula C11H13NO4
Molecular Weight 223.225
Flash Point 187.0±24.8 °C
Exact Mass 223.084457
PSA 66.84000
LogP 1.86
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.554
Storage condition Store at RT.

 MSDS

Material Safety Data Sheet
Section1. Identification of the substance
Product Name: Z-Sar-oh
Synonyms:
Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
H302:Harmful if swallowed
H411:Toxic to aquatic life with long lasting effects
P273:Avoid release to the environment
Section3. Composition/information on ingredients.
Ingredient name:Z-Sar-oh
CAS number:39608-31-6
Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.
Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.
Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Storage:Store in closed vessels.
Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.
Section9. Physical and chemical properties
Appearance:Not specified
Boiling point:No data
Melting point:No data
Flash point:No data
Density:No data
Molecular formula:C11H13NO4
Molecular weight:223.2
Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.
Section11. Toxicological information
No data.
Section12. Ecological information
No data.
Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.
Section14. Transportation information
Non-harzardous for air and ground transportation.
Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Hazard Codes Xn
Risk Phrases 22-51
HS Code 2922509090

 Synthetic Route

Sarcosine structure

Sarcosine

CAS#:107-97-1

Benzyl chloroformate structure

Benzyl chloroformate

CAS#:501-53-1

~99%

Z-Sar-OH Structure

Z-Sar-OH

CAS#:39608-31-6

Literature: Lai, Michelle Y.H.; Brimble, Margaret A.; Callis, David J.; Harris, Paul W.R.; Levi, Mark S.; Sieg, Frank Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 2 p. 533 - 548
Ethyl 2-(((benzyloxy)carbonyl)(methyl)amino)acetate structure

Ethyl 2-(((benz...

CAS#:1306592-90-4

~%

Z-Sar-OH Structure

Z-Sar-OH

CAS#:39608-31-6

Literature: JANSSEN PHARMACEUTICA NV; LANTER, James, C.; MARKOTAN, Thomas, P.; SUBASINGHE, Nalin; SUI, Zhihua Patent: WO2011/159854 A1, 2011 ; Location in patent: Page/Page column 136 ; WO 2011/159854 A1
Sarcosine structure

Sarcosine

CAS#:107-97-1

Phenyl chloroformate structure

Phenyl chloroformate

CAS#:1885-14-9

~86%

Z-Sar-OH Structure

Z-Sar-OH

CAS#:39608-31-6

Literature: Beecham Group p.l.c. Patent: US4609547 A1, 1986 ;
N-(Benzyloxycarbonyloxy)succinimide structure

N-(Benzyloxycar...

CAS#:13139-17-8

Sarcosine structure

Sarcosine

CAS#:107-97-1

~92%

Z-Sar-OH Structure

Z-Sar-OH

CAS#:39608-31-6

Literature: Negom Kouodom, Morelle; Ronconi, Luca; Celegato, Marta; Nardon, Chiara; Marchio, Luciano; Dou, Q. Ping; Aldinucci, Donatella; Formaggio, Fernando; Fregona, Dolores Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2212 - 2226
Z-Gly-OH structure

Z-Gly-OH

CAS#:1138-80-3

~%

Z-Sar-OH Structure

Z-Sar-OH

CAS#:39608-31-6

Literature: Merck and Co. Inc. Patent: US4535167 A1, 1985 ;
Sarcosine structure

Sarcosine

CAS#:107-97-1

~%

Z-Sar-OH Structure

Z-Sar-OH

CAS#:39608-31-6

Literature: Ben-Ishai; Katchalski Journal of the American Chemical Society, 1952 , vol. 74, p. 3688 Full Text View citing articles Show Details Ames et al. Journal of the Chemical Society, 1956 , p. 1984,1988 Full Text Show Details Elmore Journal of the Chemical Society, 1959 , p. 3152,3155
benzyl 5-oxo-1,3-oxazolidine-3-carboxylate structure

benzyl 5-oxo-1,...

CAS#:55740-06-2

~%

Z-Sar-OH Structure

Z-Sar-OH

CAS#:39608-31-6

Literature: Hughes, Andrew B.; Sleebs, Brad E. Helvetica Chimica Acta, 2006 , vol. 89, # 11 p. 2611 - 2637
Benzyl chloroformate structure

Benzyl chloroformate

CAS#:501-53-1

~%

Z-Sar-OH Structure

Z-Sar-OH

CAS#:39608-31-6

Literature: JANSSEN PHARMACEUTICA NV; LANTER, James, C.; MARKOTAN, Thomas, P.; SUBASINGHE, Nalin; SUI, Zhihua Patent: WO2011/159854 A1, 2011 ; WO 2011/159854 A1

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

Z-N-Me-Gly-OH
Cbz-N-methylglycine
CBZ-sarcosine
Cbz-Sar-OH
Glycine, N-methyl-N-[(phenylmethoxy)carbonyl]-
Z-SAR-OH
2-(((Benzyloxy)carbonyl)(methyl)amino)acetic acid
N-Cbz-N-methylglycine
N-[(Benzyloxy)carbonyl]-N-methylglycine
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