2-Hydroxy-3-methylbutyric acid

Modify Date: 2024-01-07 23:05:09

2-Hydroxy-3-methylbutyric acid Structure
2-Hydroxy-3-methylbutyric acid structure
Common Name 2-Hydroxy-3-methylbutyric acid
CAS Number 4026-18-0 Molecular Weight 118.131
Density 1.1±0.1 g/cm3 Boiling Point 237.6±13.0 °C at 760 mmHg
Molecular Formula C5H10O3 Melting Point 86-87ºC(lit.)
MSDS Chinese USA Flash Point 111.8±16.3 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of 2-Hydroxy-3-methylbutyric acid


2-Hydroxy-3-methylbutanoic acid is a close structure analogue of GHB, which is a naturally occurring neurotransmitter and a psychoactive drug.

 Names

Name 2-hydroxy-3-methylbutyric acid
Synonym More Synonyms

 2-Hydroxy-3-methylbutyric acid Biological Activity

Description 2-Hydroxy-3-methylbutanoic acid is a close structure analogue of GHB, which is a naturally occurring neurotransmitter and a psychoactive drug.
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Pan YM, et al. Improved procedure for the analysis of gamma-hydroxybutyrate and ethylene glycol in whole blood. J Anal Toxicol. 2001 Jul-Aug;25(5):328-32.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 237.6±13.0 °C at 760 mmHg
Melting Point 86-87ºC(lit.)
Molecular Formula C5H10O3
Molecular Weight 118.131
Flash Point 111.8±16.3 °C
Exact Mass 118.062996
PSA 57.53000
LogP 0.18
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.455

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases S26
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2918199090

 Synthetic Route

 Customs

HS Code 2918199090
Summary 2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

 Articles30

More Articles
Physiology and pathophysiology of organic acids in cerebrospinal fluid.

J. Inherit. Metab. Dis. 16(4) , 648-69, (1993)

Concentrations of organic acids in cerebrospinal fluid (CSF) appear to be directly dependent upon their rate of production in the brain. There is evidence that the net release of short-chain monocarbo...

α-Ketoisocaproic acid and leucine provoke mitochondrial bioenergetic dysfunction in rat brain

Brain Res. 1324 , 75-84, (2010)

Patients affected by maple syrup urine disease (MSUD) present severe neurological symptoms and brain abnormalities, whose pathoiphysiology is poorly known. In the present study we investigated the in ...

Renal clearance of branched-chain L-amino and 2-oxo acids in maple syrup urine disease.

J. Inherit. Metab. Dis. 22(6) , 706-22, (1999)

In maple syrup urine disease (MSUD), branched-chain L-amino (BCAA) and 2-oxo acids (BCOA) accumulate in body fluids owing to an inherited deficiency of branched-chain 2-oxo acid dehydrogenase complex ...

 Synonyms

D-Valic acid
D-2-HYDROXY-3-METHYLBUTYRIC ACID
A-hydroxyisovaleric acid
DL-2-Hydroxyisovaleric acid
2-HYDROXY-3-METHYLBU
α-hydroxyisovaleric acid
MFCD00004242
Einecs 223-697-5
UNII:02X1W97FWN
DL-a-hydroxyisovaleric acid
L-2-hydroxyisovaleric acid
2-hydroxy-3-methyl-Butyric acid
2-Oxyisovaleric Acid
2-Hydroxy-3-methylbutanoic acid
DL-2-Hydroxy-3-methylbutanoic acid
2-Hydroxy-3-methylbutyric acid
3-Methyl-2-hydroxybutyric acid
Butanoic acid, 2-hydroxy-3-methyl-
2-Hydroxy-3-methylbutyricAcid
2-Hydroxyisopentanoic acid
2-hydroxy-3-Methyl
(2S)-2-Hydroxy-3-methylbutanoic acid
2-hydroxyisovaleric acid
DL-α-hydroxyisovaleric acid
D-a-Hydroxyisovaleric acid
Butanoic acid, 2-hydroxy-3-methyl-, (2S)-
2-hydroxy-3-methyl butyric acid
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Price: ¥550/10 mM * 1 mL in DMSO

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