AMA-37 structure
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Common Name | AMA-37 | ||
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CAS Number | 404009-46-7 | Molecular Weight | 283.32200 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C17H17NO3 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of AMA-37AMA-37, an Arylmorpholine analog, is ATP-competitive DNA-PK inhibitor, with IC50 values of 0.27 μM (DNA-PK), 32 μM (p110α), 3.7 μM (p110β), and 22 μM (p110γ), respectively[1][2]. |
Name | (2-hydroxy-4-morpholin-4-ylphenyl)-phenylmethanone |
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Synonym | More Synonyms |
Description | AMA-37, an Arylmorpholine analog, is ATP-competitive DNA-PK inhibitor, with IC50 values of 0.27 μM (DNA-PK), 32 μM (p110α), 3.7 μM (p110β), and 22 μM (p110γ), respectively[1][2]. |
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Related Catalog | |
Target |
IC50: 0.27 μM (DNA-PK)[1]. |
In Vitro | AMA-37 inhbits PI3K poorly[2]. AMA-37 (20 μM) reduces the ability of UCN-01, isogranulatimide, and debromohymenialdesine, but not caffeine, to overcome G2 arrest (ρ < 0.05)[3]. Inhibition of DNA-PK with AMA37 leads to radiosensitization[3]. |
References |
Molecular Formula | C17H17NO3 |
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Molecular Weight | 283.32200 |
Exact Mass | 283.12100 |
PSA | 49.77000 |
LogP | 2.52480 |
Storage condition | -20℃ |
AMA37 |
ArylMorpholine Analog 37 |
1-(2-Hydroxy-4-morpholin-4-yl-phenyl)-phenyl-methanone |
DNA-PK Inhibitor V |