4'-demethylpodophyllotoxin

Modify Date: 2024-01-02 00:18:43

4'-demethylpodophyllotoxin structure	Common Name	4'-demethylpodophyllotoxin
	CAS Number	40505-27-9	Molecular Weight	400.37900
	Density	1.446 g/cm3	Boiling Point	626.5ºC at 760 mmHg
	Molecular Formula	C₂₁H₂₀O₈	Melting Point	N/A
	MSDS	N/A	Flash Point	224.4ºC

Use of 4'-demethylpodophyllotoxin

4'-Demethylpodophyllotoxin is an aryltetralin lignin contained in the root of Podophyllum hexandrum and P. peltatum. 4'-Demethylpodophyllotoxin exhibits cytotoxic potential in diverse cancer cell lines[1][2].

Name	4'-demethylpodophyllotoxin
Synonym	More Synonyms

Description	4'-Demethylpodophyllotoxin is an aryltetralin lignin contained in the root of Podophyllum hexandrum and P. peltatum. 4'-Demethylpodophyllotoxin exhibits cytotoxic potential in diverse cancer cell lines[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. David E.Jackson, et al. Aryltetralin lignans from Podophyllum hexandrum and Podophyllum peltatum. Phytochemistry, 1984, 23(5): 1147-1152. [2]. Zilla MK, et al. 4'-Demethyl-deoxypodophyllotoxin glucoside isolated from Podophyllum hexandrum exhibits potential anticancer activities by altering Chk-2 signaling pathway in MCF-7 breast cancer cells. Chem Biol Interact. 2014 Dec 5;224:100-7.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

References

[1]. David E.Jackson, et al. Aryltetralin lignans from Podophyllum hexandrum and Podophyllum peltatum. Phytochemistry, 1984, 23(5): 1147-1152.

[2]. Zilla MK, et al. 4'-Demethyl-deoxypodophyllotoxin glucoside isolated from Podophyllum hexandrum exhibits potential anticancer activities by altering Chk-2 signaling pathway in MCF-7 breast cancer cells. Chem Biol Interact. 2014 Dec 5;224:100-7.

Density	1.446 g/cm3
Boiling Point	626.5ºC at 760 mmHg
Molecular Formula	C₂₁H₂₀O₈
Molecular Weight	400.37900
Flash Point	224.4ºC
Exact Mass	400.11600
PSA	103.68000
LogP	2.10620
Index of Refraction	1.637
Storage condition	-20℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LV2476100

CAS REGISTRY NUMBER :: 40505-27-9

BEILSTEIN REFERENCE NO. :: 0099005

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C21-H20-O8

MOLECULAR WEIGHT :: 400.41

WISWESSER LINE NOTATION :: T E5 C665 FVO NO PO OHTT&&J DR DQ CO1 EO1& JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Human HeLa cell

DOSE/DURATION :: 40 umol/L

REFERENCE :: BICHAW Biochemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1962- Volume(issue)/page/year: 15,5443,1976

Podophyllotoxin

CAS#:518-28-5

4'-demethylpodo...

CAS#:40505-27-9

Literature: Sk, Ugir Hossain; Dixit, Deobrat; Sen, Ellora European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 47 - 57

Precursor 1
CAS#:518-28-5 Podophyllotoxin
DownStream 5
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