guanadrel

Modify Date: 2024-01-04 17:16:29

guanadrel Structure
guanadrel structure
Common Name guanadrel
CAS Number 40580-59-4 Molecular Weight 213.27700
Density 1.39g/cm3 Boiling Point 387.9ºC at 760 mmHg
Molecular Formula C10H19N3O2 Melting Point 213.5-215ºC
MSDS N/A Flash Point 188.4ºC

 Use of guanadrel


Guanadrel is an orally active postganglionic adrenergic inhibitor of spiroketal. Guanadre can be used in anti-hypertensive studies[1].

 Names

Name guanadrel
Synonym More Synonyms

 guanadrel Biological Activity

Description Guanadrel is an orally active postganglionic adrenergic inhibitor of spiroketal. Guanadre can be used in anti-hypertensive studies[1].
Related Catalog
In Vivo Guanadrel (oral gavage, 15-400 mg/kg, every day, 6-52 weeks) has little toxicity to the nervous system in rats and dogs[1]. Animal Model: Rats, dogs[1] Dosage: 15-400 mg/kg Administration: Oral gavage; every day; 6-52 weeks Result: Showed a slight increase in the weight of the prostate and adrenal glands while loss in the kidney in rats. Decreased weight gain values in a dose-dependent manner but liver function is normal in dogs.
References

[1]. J D Palmer, et al. Guanadrel sulfate: a postganglionic sympathetic inhibitor for the treatment of mild to moderate hypertension. Pharmacotherapy. 1983 Jul-Aug;3(4):220-9. doi: 10.1002/j.1875-9114.1983.tb03257.x.

 Chemical & Physical Properties

Density 1.39g/cm3
Boiling Point 387.9ºC at 760 mmHg
Melting Point 213.5-215ºC
Molecular Formula C10H19N3O2
Molecular Weight 213.27700
Flash Point 188.4ºC
Exact Mass 213.14800
PSA 80.36000
LogP 1.73620
Index of Refraction 1.618

 Synonyms

1-(1,4-Dioxaspiro[4.5]decan-2-ylmethyl)guanidine
Guanadrel