40580-59-4

40580-59-4 structure

Name: guanadrel
Chemical Name: guanadrel
CAS Number: 40580-59-4
Molecular Formula: C₁₀H₁₉N₃O₂
Molecular Weight: 213.27700
Catalog: API Circulatory system medication Antihypertensive drug
Create Date: 2018-03-09 08:00:00
Modify Date: 2024-01-04 17:16:29
Guanadrel is an orally active postganglionic adrenergic inhibitor of spiroketal. Guanadre can be used in anti-hypertensive studies[1].

Name	guanadrel
Synonyms	1-(1,4-Dioxaspiro[4.5]decan-2-ylmethyl)guanidine Guanadrel

Description	Guanadrel is an orally active postganglionic adrenergic inhibitor of spiroketal. Guanadre can be used in anti-hypertensive studies[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
In Vivo	Guanadrel (oral gavage, 15-400 mg/kg, every day, 6-52 weeks) has little toxicity to the nervous system in rats and dogs[1]. Animal Model: Rats, dogs[1] Dosage: 15-400 mg/kg Administration: Oral gavage; every day; 6-52 weeks Result: Showed a slight increase in the weight of the prostate and adrenal glands while loss in the kidney in rats. Decreased weight gain values in a dose-dependent manner but liver function is normal in dogs.
References	[1]. J D Palmer, et al. Guanadrel sulfate: a postganglionic sympathetic inhibitor for the treatment of mild to moderate hypertension. Pharmacotherapy. 1983 Jul-Aug;3(4):220-9. doi: 10.1002/j.1875-9114.1983.tb03257.x.