ANO1-IN-1

Modify Date: 2024-01-07 10:40:59

ANO1-IN-1 structure	Common Name	ANO1-IN-1
	CAS Number	407587-01-3	Molecular Weight	336.49
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₂₈N₂O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ANO1-IN-1

ANO1-IN-1 (Compound 9c) is a selective ANO1 channel blocker with an IC50 of 2.56 μM and 15.43 μM against ANO1 and ANO2, respectively. ANO1-IN-1 suppresses strongly proliferation of glioblastoma cells[1].

Name	ANO1-IN-1

Description	ANO1-IN-1 (Compound 9c) is a selective ANO1 channel blocker with an IC50 of 2.56 μM and 15.43 μM against ANO1 and ANO2, respectively. ANO1-IN-1 suppresses strongly proliferation of glioblastoma cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel
Target	IC50: 2.56 μM (ANO1), 15.43 μM (ANO2)[1]
In Vitro	ANO1-IN-1 (Compound 9c) (10 μM) significantly suppresses migration and invasion of U251 cells[1]. ANO1-IN-1 and TMZ combination brings about remarkable synergistic effects in suppressing proliferation of GBM cells[1].
References	[1]. Choi SH, et al. Anti-glioma effects of 2-aminothiophene-3-carboxamide derivatives, ANO1 channel blockers. Eur J Med Chem. 2020 Dec 15;208:112688.

Molecular Formula	C₁₈H₂₈N₂O₂S
Molecular Weight	336.49

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: ANO1-IN-1
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Purity: 99.66%
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