dexamethasone oxetanone

Modify Date: 2024-01-16 17:22:54

dexamethasone oxetanone Structure
dexamethasone oxetanone structure
 Common Name dexamethasone oxetanone
CAS Number 4089-36-5 Molecular Weight 374.44600
Density N/A Boiling Point N/A
Molecular Formula C22H27FO4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of dexamethasone oxetanone


Dexamethasone oxetanone (Dex-Ox), a derivative of the glucocorticoid-selective steroid Dexamethasone (Dex), is an antiglucocorticoid. Dexamethasone oxetanone is an antiprogestin with significant agonist activity with progesterone receptor (PR) A and B isoforms[1][2].

 Names

Name (8S,10S,11S,13S,14S,16R)-9-fluoro-11-hydroxy-10,13,16-trimethylspiro[6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17,2'-oxetane]-3,3'-dione
Synonym More Synonyms

 dexamethasone oxetanone Biological Activity

Description Dexamethasone oxetanone (Dex-Ox), a derivative of the glucocorticoid-selective steroid Dexamethasone (Dex), is an antiglucocorticoid. Dexamethasone oxetanone is an antiprogestin with significant agonist activity with progesterone receptor (PR) A and B isoforms[1][2].
Related Catalog
In Vitro Dexamethasone oxetanone (1 μM) exhibits significant quantities of agonist activity with transfected PR in CV-1 cells[2].
References

[1]. D Gagne, et al. Analysis of the relation between receptor binding affinity and antagonist efficacy of antiglucocorticoids. J Steroid Biochem. 1986 Sep;25(3):315-22.

[2]. G Giannoukos, et al. New antiprogestins with partial agonist activity: potential selective progesterone receptor modulators (SPRMs) and probes for receptor- and coregulator-induced changes in progesterone receptor induction properties. Mol Endocrinol. 2001 Feb;15(2):255-70.

 Chemical & Physical Properties

Molecular Formula C22H27FO4
Molecular Weight 374.44600
Exact Mass 374.18900
PSA 63.60000
LogP 2.94130

 Synonyms

Dexamethasone oxetanone
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Chemsrc provides dexamethasone oxetanone(CAS#:4089-36-5) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of dexamethasone oxetanone are included as well.>> amp version: dexamethasone oxetanone

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