Neuropeptide S (human) trifluoroacetate salt

Modify Date: 2024-01-02 12:31:29

Neuropeptide S (human) trifluoroacetate salt structure	Common Name	Neuropeptide S (human) trifluoroacetate salt
	CAS Number	412938-67-1	Molecular Weight	2187.48000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₉₃H₁₅₅N₃₁O₂₈S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Neuropeptide S (human) trifluoroacetate salt

Neuropeptide S human is a potent endogenous neuropeptide S receptor agonist (EC50= 9.4 nM). Neuropeptide S human increases locomotor activity and wakefulness in mice. Neuropeptide S human also reduces anxiety-like behavior in mice.

Name	neuropeptide s (human)
Synonym	More Synonyms

Description	Neuropeptide S human is a potent endogenous neuropeptide S receptor agonist (EC50= 9.4 nM). Neuropeptide S human increases locomotor activity and wakefulness in mice. Neuropeptide S human also reduces anxiety-like behavior in mice.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	EC50: 9.4 nM (neuropeptide S receptor)[1]
In Vitro	Neuropeptide S (human)(4 pM to 1.7 nM; 48 hours)retains full agonist activity with an EC50 of 6.7 ± 2.4 nM, the binding of [125I] Y10-hNPS to CHO cells stably expressing hNPSR is saturable with high affinity (Kd = 0.33 ± 0.12 nM)[1]. Neuropeptide S (human)(1 pM - 3 μM; 48 hours) are used to compete with 0.15 nM [125I] Y10-NPS, [125I] Y10-NPS is displaceable by increasing concentrations of human NPS (IC50 = 0.42 ± 0.12 nM) [1].
In Vivo	Neuropeptide S (human) (intracerebroventricular (i.c.v.) injection; 0.1 nMor 1 nM; 60 mins) causes a significant increase in locomotor activity, the total distance traveled, percentage of time moving, number of rearing events, and center entries are also significantly increased in mice.