412938-67-1

412938-67-1 structure

Name: Neuropeptide S (human) trifluoroacetate salt
Chemical Name: neuropeptide s (human)
CAS Number: 412938-67-1
Molecular Formula: C₉₃H₁₅₅N₃₁O₂₈S
Molecular Weight: 2187.48000
Catalog: Research Areas Neurological Disease
Create Date: 2016-12-27 08:36:00
Modify Date: 2024-01-02 12:31:29
Neuropeptide S human is a potent endogenous neuropeptide S receptor agonist (EC50= 9.4 nM). Neuropeptide S human increases locomotor activity and wakefulness in mice. Neuropeptide S human also reduces anxiety-like behavior in mice.

Name	neuropeptide s (human)
Synonyms	SFRNGVGTGMKKTSFQRAKS H-SER-PHE-ARG-ASN-GLY-VAL-GLY-THR-GLY-MET-LYS-LYS-THR-SER-PHE-GLN-ARG-ALA-LYS-SER-OH Neuropeptide S,NPS,human SER-PHE-ARG-ASN-GLY-VAL-GLY-THR-GLY-MET-LYS-LYS-THR-SER-PHE-GLN-ARG-ALA-LYS-SER REF DUPL: H-Ser-Phe-Arg-Asn-Gly-Val-Gly-Ser-Gly-Ala-Lys-Lys-Thr-Ser-Phe-Arg-Arg-Ala-Lys-Gln-OH

Description	Neuropeptide S human is a potent endogenous neuropeptide S receptor agonist (EC50= 9.4 nM). Neuropeptide S human increases locomotor activity and wakefulness in mice. Neuropeptide S human also reduces anxiety-like behavior in mice.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	EC50: 9.4 nM (neuropeptide S receptor)[1]
In Vitro	Neuropeptide S (human)(4 pM to 1.7 nM; 48 hours)retains full agonist activity with an EC50 of 6.7 ± 2.4 nM, the binding of [125I] Y10-hNPS to CHO cells stably expressing hNPSR is saturable with high affinity (Kd = 0.33 ± 0.12 nM)[1]. Neuropeptide S (human)(1 pM - 3 μM; 48 hours) are used to compete with 0.15 nM [125I] Y10-NPS, [125I] Y10-NPS is displaceable by increasing concentrations of human NPS (IC50 = 0.42 ± 0.12 nM) [1].
In Vivo	Neuropeptide S (human) (intracerebroventricular (i.c.v.) injection; 0.1 nMor 1 nM; 60 mins) causes a significant increase in locomotor activity, the total distance traveled, percentage of time moving, number of rearing events, and center entries are also significantly increased in mice.