Crocin

Modify Date: 2024-01-05 10:24:14

Crocin Structure
Crocin structure
 Common Name Crocin
CAS Number 42553-65-1 Molecular Weight 976.965
Density 1.5±0.1 g/cm3 Boiling Point 1169.0±65.0 °C at 760 mmHg
Molecular Formula C44H64O24 Melting Point 186° (effervescence)
MSDS Chinese USA Flash Point 337.8±27.8 °C

 Use of Crocin


Crocin is a nutraceutical and the main constituent isolated from the stigmas of Crocus sativus with immense pharmacological properties as anti-inflammatory, anticancer, antidepressant and anticonvulsant[1].

 Names

Name Crocin (Gardenia Fruits Extract)
Synonym More Synonyms

 Crocin Biological Activity

Description Crocin is a nutraceutical and the main constituent isolated from the stigmas of Crocus sativus with immense pharmacological properties as anti-inflammatory, anticancer, antidepressant and anticonvulsant[1].
Related Catalog
References

[1]. Zaghloul MS, et al. Crocin attenuates lung inflammation and pulmonary vascular dysfunction in a rat model of bleomycin-induced pulmonary fibrosis. Life Sci. 2019 Aug 26:116794.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 1169.0±65.0 °C at 760 mmHg
Melting Point 186° (effervescence)
Molecular Formula C44H64O24
Molecular Weight 976.965
Flash Point 337.8±27.8 °C
Exact Mass 976.378723
PSA 391.20000
LogP -0.83
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.650
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HL7380000
CHEMICAL NAME :
8,8'-Diapo-psi,psi-carotenedioic acid, bis(6-O-beta-D-glucopyranosyl-beta-D- glucopyranosyl) ester
CAS REGISTRY NUMBER :
42553-65-1
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C44-H64-O24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
10 gm/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - altered sleep time (including change in righting reflex) Behavioral - changes in motor activity (specific assay)
REFERENCE :
JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 4,69,1954

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Safety Phrases 24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS HL7380000
HS Code 32129000

 Synthetic Route

Crocin Structure

Crocin

CAS#:42553-65-1

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Crocin Structure

Crocin

CAS#:42553-65-1

Literature: Speranza, Giovanna; Dada, Giuseppe; Manitto, Paolo; Monti, Diego; Gramatica, Paola Gazzetta Chimica Italiana, 1984 , vol. 114, # 3/4 p. 189 - 192

 Precursor & DownStream

Precursor  1

DownStream  2

 Articles50

More Articles
Gastroprotective effect of crocin in ethanol-induced gastric injury in rats.

Chem. Biol. Interact. 229 , 26-35, (2015)

The present study investigated the gastroprotective effect of crocin in ethanol-induced gastric injury in rats. Rats were allocated into a normal group, an ulcer group, a crocin-treated group, an ulce...

The Gardenia jasminoides extract and its constituent, geniposide, elicit anti-allergic effects on atopic dermatitis by inhibiting histamine in vitro and in vivo.

J. Ethnopharmacol. 156 , 33-40, (2014)

Gardenia jasminoides Ellis has been used in traditional medicine for treatment of inflammation, edema, and dermaitis. The aim of this study was to investigate the mechanism by which Gardenia jasminoid...

Crocin prevents sesamol-induced oxidative stress and apoptosis in human platelets.

J. Thromb. Thrombolysis 38(3) , 321-30, (2014)

Recent studies have reported the platelet proapoptotic propensity of plant-derived molecules such as, resveratrol, thymoquinone, andrographolide and gossypol. Meanwhile, there were also reports of phy...

 Synonyms

Crocetin digentiobiose ester
Bis[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl] (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate
EINECS 255-881-6
MFCD00017495
Bis[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl] (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate (non-preferred name)
CROCIN
8,8'-Diapo-y,y-carotenedioic acid bis(6-O-b-D-glucopyranosyl-b-D-glucopyranosyl) ester
Digentiobiosyl 8,8'-Diapo-8,8'-carotenedioate
Crocetin Digentiobiosyl Ester (Gardenia Fruits Extract)
a-Crocin
Bis[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-({[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}methyl)tetrahydro-2H-pyran-2-yl] (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethyl-2,4,6,8,10,12,14-hexadecaheptaenedioate (non-preferred name)
Crocetin Digentiobiosyl Ester
Crocin 1
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CrocinI
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crocin-4
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crocin-1
39465-00-4
Crocin III
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